SRR1311182
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.308
- KRAS_SIGNALING_DN+0.207
- SPERMATOGENESIS+0.151
- HEDGEHOG_SIGNALING+0.120
- OXIDATIVE_PHOSPHORYLATION+0.037
- PEROXISOME+0.023
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.012
- APICAL_SURFACE-0.038
- MYOGENESIS-0.079
- GLYCOLYSIS-0.096
Top 10 suppressed
- G2M_CHECKPOINT-0.517
- TNFA_SIGNALING_VIA_NFKB-0.500
- TGF_BETA_SIGNALING-0.476
- IL6_JAK_STAT3_SIGNALING-0.470
- MITOTIC_SPINDLE-0.457
- E2F_TARGETS-0.453
- ANGIOGENESIS-0.441
- ANDROGEN_RESPONSE-0.389
- INFLAMMATORY_RESPONSE-0.362
- MYC_TARGETS_V1-0.343
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1319837 | GTEX | — | 0.966 |
| 2 | SRR1316921 | GTEX | — | 0.956 |
| 3 | SRR1443713 | GTEX | — | 0.946 |
| 4 | SRR1319970 | GTEX | — | 0.945 |
| 5 | SRR1334717 | GTEX | — | 0.939 |
| 6 | SRR1414897 | GTEX | — | 0.933 |
| 7 | SRR1321183 | GTEX | — | 0.930 |
| 8 | SRR1464327 | GTEX | — | 0.928 |
| 9 | SRR1317596 | GTEX | — | 0.926 |
| 10 | SRR1329334 | GTEX | — | 0.925 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.308 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.207 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.151 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.120 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.037 | Remibrutinib | — uncovered |
| PEROXISOME | 0.023 | Idelalisib | — uncovered |