SRR1430817
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.243
- TNFA_SIGNALING_VIA_NFKB+0.216
- KRAS_SIGNALING_DN+0.183
- G2M_CHECKPOINT+0.122
- UNFOLDED_PROTEIN_RESPONSE+0.114
- UV_RESPONSE_UP+0.071
- ANDROGEN_RESPONSE+0.067
- P53_PATHWAY+0.062
- PI3K_AKT_MTOR_SIGNALING+0.060
- PANCREAS_BETA_CELLS+0.048
Top 10 suppressed
- NOTCH_SIGNALING-0.504
- INTERFERON_ALPHA_RESPONSE-0.475
- OXIDATIVE_PHOSPHORYLATION-0.466
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.413
- ADIPOGENESIS-0.365
- INTERFERON_GAMMA_RESPONSE-0.357
- ANGIOGENESIS-0.326
- FATTY_ACID_METABOLISM-0.310
- UV_RESPONSE_DN-0.288
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.272
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1315799 | GTEX | — | 0.913 |
| 2 | SRR820107 | GTEX | — | 0.886 |
| 3 | SRR658813 | GTEX | — | 0.869 |
| 4 | SRR655375 | GTEX | — | 0.863 |
| 5 | SRR1383633 | GTEX | — | 0.852 |
| 6 | SRR1466357 | GTEX | — | 0.851 |
| 7 | SRR1480875 | GTEX | — | 0.851 |
| 8 | SRR1479912 | GTEX | — | 0.843 |
| 9 | SRR1093527 | GTEX | — | 0.842 |
| 10 | SRR1335856 | GTEX | — | 0.834 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.243 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.216 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.183 | Remibrutinib | — uncovered |
| G2M_CHECKPOINT | 0.122 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.114 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.071 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.067 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.062 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.060 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.048 | Cobimetinib | — uncovered |
| E2F_TARGETS | 0.045 | Inavolisib | — uncovered |