Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SAMN03290901

916704a9-05df-5954-b681-c92fc09c95b6

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • COAGULATION+0.400
  • ESTROGEN_RESPONSE_EARLY+0.400
  • ESTROGEN_RESPONSE_LATE+0.400
  • APICAL_SURFACE+0.300
  • COMPLEMENT+0.300
  • INTERFERON_ALPHA_RESPONSE+0.300
  • KRAS_SIGNALING_DN+0.300
  • PANCREAS_BETA_CELLS+0.300
  • XENOBIOTIC_METABOLISM+0.300
  • APICAL_JUNCTION+0.200

Top 10 suppressed

  • E2F_TARGETS-0.400
  • G2M_CHECKPOINT-0.400
  • MITOTIC_SPINDLE-0.400
  • PROTEIN_SECRETION-0.400
  • UNFOLDED_PROTEIN_RESPONSE-0.400
  • UV_RESPONSE_DN-0.400
  • MYC_TARGETS_V1-0.300
  • ANGIOGENESIS-0.200
  • MYC_TARGETS_V2-0.200
  • TNFA_SIGNALING_VIA_NFKB-0.200

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1SAMN03290893
melanoma-umap@29
0.868
2SAMN03290919
melanoma-umap@29
0.842
3SRR1433600
brain-umap@2
GTEX0.834
4SRR1419148
brain-umap@2
GTEX0.819
5SAMN03290907
melanoma-umap@29
0.818
6MDT-AP-0720
medullo-epn-umap@date-based
MedMedulloblastoma0.818
7SRR1080172
brain-umap@2
GTEX0.807
8ERR2598280
medullo-epn-umap@date-based
fetalfetal0.799
9TCGA-BH-A5J0-01A-11R-A27Q-07
breast-umap@18
B0.794
10SAMN03290904
melanoma-umap@29
0.788

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
COAGULATION0.400Binimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.400Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.400Idelalisib— uncovered
APICAL_SURFACE0.300Temsirolimus— uncovered
COMPLEMENT0.300Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.300Inavolisib— uncovered
KRAS_SIGNALING_DN0.300Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.300Cobimetinib— uncovered
XENOBIOTIC_METABOLISM0.300Inavolisib— uncovered
APICAL_JUNCTION0.200Inavolisib— uncovered
FATTY_ACID_METABOLISM0.200Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.200Idelalisib— uncovered
MYOGENESIS0.200Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.200Remibrutinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.200Inavolisib— uncovered
ADIPOGENESIS0.100Inavolisib— uncovered
ALLOGRAFT_REJECTION0.100Idelalisib— uncovered
APOPTOSIS0.100Idelalisib— uncovered
BILE_ACID_METABOLISM0.100Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.100Inavolisib— uncovered