Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-FT-A3EE-01A-11R-A206-07

92aa2035-2817-5e45-8854-e8778b5cdd2a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
3.252299606
os_event
true
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.480
  • TGF_BETA_SIGNALING+0.390
  • UNFOLDED_PROTEIN_RESPONSE+0.370
  • ESTROGEN_RESPONSE_EARLY+0.350
  • ANGIOGENESIS+0.340
  • ANDROGEN_RESPONSE+0.330
  • PROTEIN_SECRETION+0.330
  • MYC_TARGETS_V1+0.290
  • MTORC1_SIGNALING+0.270
  • P53_PATHWAY+0.260

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.550
  • INTERFERON_GAMMA_RESPONSE-0.440
  • E2F_TARGETS-0.260
  • ALLOGRAFT_REJECTION-0.220
  • G2M_CHECKPOINT-0.170
  • DNA_REPAIR-0.160
  • APICAL_SURFACE-0.150
  • IL6_JAK_STAT3_SIGNALING-0.150
  • XENOBIOTIC_METABOLISM-0.130
  • MYOGENESIS-0.110

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-BH-A0HX-01A-21R-A056-07
breast-umap@18
B0.721
2eaecaea1-2cb7-472c-b549-ff779e5e1d30
melanoma-umap@29
0.719
3TCGA-P3-A6T3-01A-11R-A34R-07
head-neck@1
0.713
4MNG578
mng-umap@100
0.705
5SRR12202472
bladder-landscape@3
0.702
6DRR168536
bladder-landscape@3
0.693
7TCGA-CR-7379-01A-11R-2016-07
head-neck@1
0.692
8ERR2278862
head-neck@1
0.683
9DRR168531
bladder-landscape@3
0.678
10MNG1073
mng-umap@100
0.676

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 31 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.480Idelalisib— uncovered
TGF_BETA_SIGNALING0.390Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.370Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.350Inavolisib— uncovered
ANGIOGENESIS0.340Remibrutinib— uncovered
ANDROGEN_RESPONSE0.330Inavolisib— uncovered
PROTEIN_SECRETION0.330Remibrutinib— uncovered
MYC_TARGETS_V10.290Inavolisib— uncovered
MTORC1_SIGNALING0.270Inavolisib— uncovered
P53_PATHWAY0.260Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.210Inavolisib— uncovered
PEROXISOME0.200Idelalisib— uncovered
APICAL_JUNCTION0.180Inavolisib— uncovered
KRAS_SIGNALING_UP0.170Inavolisib— uncovered
UV_RESPONSE_DN0.170Inavolisib— uncovered
GLYCOLYSIS0.150Inavolisib— uncovered
NOTCH_SIGNALING0.150Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.150Remibrutinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.150Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.140Idelalisib— uncovered