Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-B6-A0RO-01A-22R-A084-07

· C

93382634-221b-5a26-9a3a-f6483de23f32

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C
overall_survival_months
164

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-D8-A1JS-01A-11R-A13Q-07
breast-umap@18
B0.884
2SRR8518413
breast-umap@18
F0.881
3SRR8518189
breast-umap@18
F0.867
4TCGA-78-7163-01A-12R-2066-07
lung-landscapes@6
cohortA10.864
5SRR8943024
bladder-landscape@3
0.864
6TCGA-BH-A18S-01A-11R-A12D-07
breast-umap@18
B0.861
7SRR6013501
lung-landscapes@6
cohortA10.861
8TCGA-A8-A07P-01A-11R-A00Z-07
breast-umap@18
B0.855
9TCGA-C8-A133-01A-32R-A12D-07
breast-umap@18
B0.848
10AUR-AFUP-TTM1-A-1-1-R-A743-41
breast-umap@18
B0.847

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.490Remibrutinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.480Remibrutinib— uncovered
PEROXISOME0.380Idelalisib— uncovered
ADIPOGENESIS0.360Inavolisib— uncovered
FATTY_ACID_METABOLISM0.350Inavolisib— uncovered
BILE_ACID_METABOLISM0.340Inavolisib— uncovered
ANDROGEN_RESPONSE0.300Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.270Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.240Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.230Inavolisib— uncovered
NOTCH_SIGNALING0.210Inavolisib— uncovered
GLYCOLYSIS0.200Inavolisib— uncovered
MTORC1_SIGNALING0.190Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.190Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.170Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.170Idelalisib— uncovered
HEME_METABOLISM0.120Temsirolimus— uncovered
CHOLESTEROL_HOMEOSTASIS0.100Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.090Cobimetinib— uncovered
UV_RESPONSE_UP0.090Idelalisib— uncovered