Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_N5DVEJXT

Supratentorial Ependymoma

9477f723-40a8-5e40-a6ee-28af2827424d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Supratentorial Ependymoma
cancer_type_detailed
subtype
cancer_type
Supratentorial Ependymoma
overall_survival_months
9.921156373193167
age_years
0.63
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • E2F_TARGETS+0.453
  • G2M_CHECKPOINT+0.449
  • WNT_BETA_CATENIN_SIGNALING+0.409
  • DNA_REPAIR+0.371
  • NOTCH_SIGNALING+0.303
  • MITOTIC_SPINDLE+0.178
  • INTERFERON_ALPHA_RESPONSE+0.165
  • MYC_TARGETS_V2+0.148
  • MYC_TARGETS_V1+0.105
  • SPERMATOGENESIS+0.086

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.429
  • KRAS_SIGNALING_UP-0.420
  • INFLAMMATORY_RESPONSE-0.415
  • IL6_JAK_STAT3_SIGNALING-0.393
  • PROTEIN_SECRETION-0.379
  • COMPLEMENT-0.364
  • TNFA_SIGNALING_VIA_NFKB-0.345
  • IL2_STAT5_SIGNALING-0.294
  • ANDROGEN_RESPONSE-0.279
  • COAGULATION-0.254

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_N5DVEJXT
medullo-epn-umap@date-based
EPNSupratentorial EPN0.928
2BS_5P1TN10Z
brain-umap@2
Embryonal tumors0.829
3BS_NB42PWZN
brain-umap@2
Supratentorial Ependymoma0.825
4BS_VAAHBH60
brain-umap@2
Supratentorial Ependymoma0.824
5BS_1EN5V3XW
brain-umap@2
high-grade glioma0.820
6eb5ad680-6080-41fe-982e-e46f90c3849f
colon-landscapes@1
0.815
719-007D5_Primary
bladder-landscape@3
0.813
8TCGA-98-A53A-01A-11R-A262-07
lung-landscapes@6
cohortSQ10.811
9BS_M0QYNVK8
brain-umap@2
high-grade glioma0.809
10BS_K25F4J3V
brain-umap@2
ATRT0.806

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 15 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.453Inavolisib— uncovered
G2M_CHECKPOINT0.449Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.409Inavolisib— uncovered
DNA_REPAIR0.371Idelalisib— uncovered
NOTCH_SIGNALING0.303Inavolisib— uncovered
MITOTIC_SPINDLE0.178Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.165Inavolisib— uncovered
MYC_TARGETS_V20.148Idelalisib— uncovered
MYC_TARGETS_V10.105Inavolisib— uncovered
SPERMATOGENESIS0.086Inavolisib— uncovered
UV_RESPONSE_UP0.077Idelalisib— uncovered
KRAS_SIGNALING_DN0.039Remibrutinib— uncovered
TGF_BETA_SIGNALING0.019Inavolisib— uncovered
GLYCOLYSIS0.018Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.014Idelalisib— uncovered