eb5ad680-6080-41fe-982e-e46f90c3849f
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 42
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.420
- MYC_TARGETS_V2+0.390
- G2M_CHECKPOINT+0.340
- E2F_TARGETS+0.300
- MITOTIC_SPINDLE+0.210
- WNT_BETA_CATENIN_SIGNALING+0.130
- DNA_REPAIR+0.100
- NOTCH_SIGNALING+0.080
- SPERMATOGENESIS+0.080
- MYOGENESIS+0.070
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.470
- IL6_JAK_STAT3_SIGNALING-0.420
- ANDROGEN_RESPONSE-0.370
- INFLAMMATORY_RESPONSE-0.360
- TNFA_SIGNALING_VIA_NFKB-0.360
- CHOLESTEROL_HOMEOSTASIS-0.350
- HEDGEHOG_SIGNALING-0.340
- MTORC1_SIGNALING-0.340
- COMPLEMENT-0.330
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BSR_21_0015_A1_S76 | — | B | 0.830 |
| 2 | SRR8613722 | — | E | 0.820 |
| 3 | 2d8478f6-41ac-47f5-ac3c-337af7245f5b | — | — | 0.818 |
| 4 | BS_N5DVEJXT | Supratentorial Ependymoma | — | 0.815 |
| 5 | BS_2A5R9MEJ | high-grade glioma | — | 0.813 |
| 6 | R4 | — | — | 0.811 |
| 7 | SRR8942965 | — | — | 0.799 |
| 8 | TCGA-E9-A247-01A-11R-A169-07 | — | B | 0.799 |
| 9 | 02c0aa6a-a7ea-4606-8449-7437df54802c | — | — | 0.797 |
| 10 | BS_N5DVEJXT | EPN | Supratentorial EPN | 0.796 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.420 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.390 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.340 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.300 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.210 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.130 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.100 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.080 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.080 | Inavolisib | — uncovered |
| MYOGENESIS | 0.070 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.060 | Inavolisib | — uncovered |