Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG385

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94b88200-3fc4-57c7-a4f7-3a750677aa07

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.493
  • UV_RESPONSE_DN+0.422
  • INTERFERON_GAMMA_RESPONSE+0.387
  • IL6_JAK_STAT3_SIGNALING+0.295
  • TGF_BETA_SIGNALING+0.290
  • PROTEIN_SECRETION+0.283
  • FATTY_ACID_METABOLISM+0.276
  • OXIDATIVE_PHOSPHORYLATION+0.263
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.259
  • PEROXISOME+0.258

Top 10 suppressed

  • MYC_TARGETS_V2-0.320
  • PANCREAS_BETA_CELLS-0.296
  • MTORC1_SIGNALING-0.260
  • G2M_CHECKPOINT-0.220
  • MYC_TARGETS_V1-0.205
  • COAGULATION-0.190
  • KRAS_SIGNALING_DN-0.162
  • GLYCOLYSIS-0.101
  • CHOLESTEROL_HOMEOSTASIS-0.066
  • E2F_TARGETS-0.061

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG177
mng-umap@100
——0.815
2MNG1060
mng-umap@100
——0.722
3MNG693
mng-umap@100
——0.718
4BS_T4JFN54G
brain-umap@2
low-grade glioma—0.693
5TCGA-A2-A0YC-01A-11R-A109-07
breast-umap@18
—B0.684
6MNG1182
mng-umap@100
——0.679
7BS_V0Q1G94N
brain-umap@2
low-grade glioma—0.677
8BS_TYKJ8G2G
brain-umap@2
Schwannoma—0.672
9SRR934843
brain-umap@2
——0.671
10MDT-AP-0220
medullo-epn-umap@date-based
MedMedulloblastoma0.670

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 31 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.493Inavolisib— uncovered
UV_RESPONSE_DN0.422Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.387Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.295Inavolisib— uncovered
TGF_BETA_SIGNALING0.290Inavolisib— uncovered
PROTEIN_SECRETION0.283Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.276Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.263Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.259Inavolisib— uncovered
PEROXISOME0.258Idelalisib— uncovered
ADIPOGENESIS0.248Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.237Inavolisib— uncovered
BILE_ACID_METABOLISM0.219Inavolisib— uncovered
DNA_REPAIR0.216Idelalisib— uncovered
MITOTIC_SPINDLE0.213Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.176Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.163Inavolisib— uncovered
HEDGEHOG_SIGNALING0.153Inavolisib— uncovered
IL2_STAT5_SIGNALING0.133Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.133Inavolisib— uncovered