Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG1182

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12d68565-cb36-53f7-ac7c-bebf40739c9c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.469
  • IL6_JAK_STAT3_SIGNALING+0.369
  • WNT_BETA_CATENIN_SIGNALING+0.369
  • PROTEIN_SECRETION+0.333
  • MITOTIC_SPINDLE+0.293
  • ADIPOGENESIS+0.290
  • INTERFERON_GAMMA_RESPONSE+0.265
  • PI3K_AKT_MTOR_SIGNALING+0.261
  • DNA_REPAIR+0.258
  • UV_RESPONSE_DN+0.245

Top 10 suppressed

  • TNFA_SIGNALING_VIA_NFKB-0.263
  • PANCREAS_BETA_CELLS-0.186
  • KRAS_SIGNALING_DN-0.139
  • HEDGEHOG_SIGNALING-0.109
  • SPERMATOGENESIS-0.108
  • E2F_TARGETS-0.103
  • HYPOXIA-0.086
  • ESTROGEN_RESPONSE_LATE-0.055
  • MTORC1_SIGNALING-0.048
  • UV_RESPONSE_UP-0.038

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG1046
mng-umap@100
——0.797
2MNG1199
mng-umap@100
——0.784
3MNG1060
mng-umap@100
——0.779
4MNG1047
mng-umap@100
——0.759
5SRR934833
brain-umap@2
——0.756
6MNG525
mng-umap@100
——0.749
7MNG1167
mng-umap@100
——0.732
8MNG181
mng-umap@100
——0.731
9MNG596
mng-umap@100
——0.717
10BS_A3QZB9Y2
brain-umap@2
Meningioma—0.716

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.469Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.369Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.369Inavolisib— uncovered
PROTEIN_SECRETION0.333Remibrutinib— uncovered
MITOTIC_SPINDLE0.293Inavolisib— uncovered
ADIPOGENESIS0.290Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.265Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.261Inavolisib— uncovered
DNA_REPAIR0.258Idelalisib— uncovered
UV_RESPONSE_DN0.245Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.198Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.193Remibrutinib— uncovered
HEME_METABOLISM0.181Temsirolimus— uncovered
APOPTOSIS0.168Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.167Inavolisib— uncovered
TGF_BETA_SIGNALING0.167Inavolisib— uncovered
P53_PATHWAY0.165Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.161Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.145Inavolisib— uncovered
COMPLEMENT0.143Inavolisib— uncovered