Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-A7-A26G-01A-21R-A169-07

· D

9501111e-397f-5b7e-9c6a-79de943d585a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D
overall_survival_months
24

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.500
  • ANGIOGENESIS+0.460
  • PROTEIN_SECRETION+0.450
  • KRAS_SIGNALING_UP+0.420
  • INFLAMMATORY_RESPONSE+0.380
  • TGF_BETA_SIGNALING+0.360
  • ALLOGRAFT_REJECTION+0.350
  • UV_RESPONSE_DN+0.350
  • COMPLEMENT+0.340
  • HEDGEHOG_SIGNALING+0.300

Top 10 suppressed

  • OXIDATIVE_PHOSPHORYLATION-0.420
  • ESTROGEN_RESPONSE_LATE-0.370
  • ESTROGEN_RESPONSE_EARLY-0.360
  • DNA_REPAIR-0.290
  • INTERFERON_ALPHA_RESPONSE-0.250
  • FATTY_ACID_METABOLISM-0.230
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.200
  • MYOGENESIS-0.140
  • MYC_TARGETS_V1-0.120
  • KRAS_SIGNALING_DN-0.110

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-60-2704-01A-11R-2045-07
lung-landscapes@6
cohortSQ10.851
2TCGA-HD-7753-01A-11R-2081-07
head-neck@1
0.836
3SAMN03290934
melanoma-umap@29
0.832
4TCGA-BH-A1EO-01A-11R-A137-07
breast-umap@18
A0.821
5DRR168609
bladder-landscape@3
0.818
6TCGA-A8-A07E-01A-11R-A034-07
breast-umap@18
A0.799
7TCGA-BH-A1FU-01A-11R-A14D-07
breast-umap@18
C0.796
8TCGA-BH-A0AV-01A-31R-A115-07
breast-umap@18
E0.790
9TCGA-A8-A08Z-01A-21R-A00Z-07
breast-umap@18
A0.787
10SRR15030887
colon-landscapes@1
0.780

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.500Inavolisib— uncovered
ANGIOGENESIS0.460Remibrutinib— uncovered
PROTEIN_SECRETION0.450Remibrutinib— uncovered
KRAS_SIGNALING_UP0.420Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.380Idelalisib— uncovered
TGF_BETA_SIGNALING0.360Inavolisib— uncovered
ALLOGRAFT_REJECTION0.350Idelalisib— uncovered
UV_RESPONSE_DN0.350Inavolisib— uncovered
COMPLEMENT0.340Inavolisib— uncovered
HEDGEHOG_SIGNALING0.300Inavolisib— uncovered
IL2_STAT5_SIGNALING0.300Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.280Inavolisib— uncovered
NOTCH_SIGNALING0.260Inavolisib— uncovered
ANDROGEN_RESPONSE0.220Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.220Inavolisib— uncovered
COAGULATION0.210Binimetinib— uncovered
G2M_CHECKPOINT0.180Inavolisib— uncovered
MITOTIC_SPINDLE0.150Inavolisib— uncovered
APICAL_JUNCTION0.110Inavolisib— uncovered
E2F_TARGETS0.110Inavolisib— uncovered