BS_J6VKB1VE

low-grade glioma

95ef031c-f16e-592a-ac2c-7e50259fe39d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: low-grade glioma
cancer_type_detailed: —
subtype: —
cancer_type: low-grade glioma
age_years: 8.238
sex: Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

HTTPException: HTTP Error: HTTP GET error on 'https://pub-e056b053afc04eec88337b62541f3025.r2.dev/oncoscape/brain-umap/2/gsva.parquet' (HTTP 429 Too Many Requests) LINE 1: SELECT pathway_library_id, pathway_name, gsva_score FROM read_parquet('https://pub-e056b053afc04eec88337b62541f3025... ^

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR1313132 breast-umap@18	—	D	0.891
2	be8d8236-4ebc-46de-a4fd-a901fec1cdce melanoma-umap@29	—	—	0.888
3	BS_25T139TX brain-umap@2	low-grade glioma	—	0.869
4	SRR8518220 breast-umap@18	—	D	0.869
5	bae6fdb5-9df3-433c-9a4c-e5c159a62bc6 colon-landscapes@1	—	—	0.864
6	TCGA-93-A4JQ-01A-11R-A24X-07 lung-landscapes@6	—	cohortA1	0.863
7	e07c111b-da6e-4743-9351-77491153bec4 melanoma-umap@29	—	—	0.859
8	AUR-AE6X-TTP1-A-1-0-R-A741-41 breast-umap@18	—	D	0.857
9	TCGA-93-A4JO-01A-21R-A24X-07 lung-landscapes@6	—	cohortA1	0.857
10	C3N-00433 lung-landscapes@6	—	cohortMD2	0.856

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 15 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
INTERFERON_ALPHA_RESPONSE	0.399	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.399	Idelalisib	— uncovered
ALLOGRAFT_REJECTION	0.314	Idelalisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.300	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.213	Idelalisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.186	Inavolisib	— uncovered
ANGIOGENESIS	0.171	Remibrutinib	— uncovered
KRAS_SIGNALING_UP	0.165	Inavolisib	— uncovered
IL2_STAT5_SIGNALING	0.164	Idelalisib	— uncovered
APICAL_SURFACE	0.141	Temsirolimus	— uncovered
COMPLEMENT	0.100	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.021	Remibrutinib	— uncovered
NOTCH_SIGNALING	0.015	Inavolisib	— uncovered
COAGULATION	0.008	Binimetinib	— uncovered
UV_RESPONSE_DN	0.005	Inavolisib	— uncovered