Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1320916

GTEX

9ba10dff-fc02-5ecd-8c1e-0a1f0874adf9

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.396
  • PANCREAS_BETA_CELLS+0.386
  • INTERFERON_GAMMA_RESPONSE+0.279
  • KRAS_SIGNALING_DN+0.242
  • ALLOGRAFT_REJECTION+0.213
  • APICAL_SURFACE+0.188
  • INFLAMMATORY_RESPONSE+0.174
  • SPERMATOGENESIS+0.130
  • IL2_STAT5_SIGNALING+0.096
  • KRAS_SIGNALING_UP+0.051

Top 10 suppressed

  • OXIDATIVE_PHOSPHORYLATION-0.573
  • MYC_TARGETS_V1-0.565
  • MYC_TARGETS_V2-0.468
  • G2M_CHECKPOINT-0.444
  • E2F_TARGETS-0.436
  • DNA_REPAIR-0.429
  • MITOTIC_SPINDLE-0.399
  • UNFOLDED_PROTEIN_RESPONSE-0.381
  • ADIPOGENESIS-0.370
  • PI3K_AKT_MTOR_SIGNALING-0.341

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1429725
brain-umap@2
GTEX0.940
2SRR1446892
brain-umap@2
GTEX0.911
3SRR1421198
brain-umap@2
GTEX0.909
4SRR1413454
brain-umap@2
GTEX0.896
5SRR1325927
brain-umap@2
GTEX0.890
6ee0e68bf-7fa0-4edc-a9df-30a63c2db34a
melanoma-umap@29
0.889
7SRR8942994
bladder-landscape@3
0.889
8MNG450
mng-umap@100
0.881
9MNG1098
mng-umap@100
0.879
10SRR650162
bladder-landscape@3
0.879

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.396Inavolisib— uncovered
PANCREAS_BETA_CELLS0.386Cobimetinib— uncovered
INTERFERON_GAMMA_RESPONSE0.279Idelalisib— uncovered
KRAS_SIGNALING_DN0.242Remibrutinib— uncovered
ALLOGRAFT_REJECTION0.213Idelalisib— uncovered
APICAL_SURFACE0.188Temsirolimus— uncovered
INFLAMMATORY_RESPONSE0.174Idelalisib— uncovered
SPERMATOGENESIS0.130Inavolisib— uncovered
IL2_STAT5_SIGNALING0.096Idelalisib— uncovered
KRAS_SIGNALING_UP0.051Inavolisib— uncovered
BILE_ACID_METABOLISM0.045Inavolisib— uncovered
HEDGEHOG_SIGNALING0.030Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.025Idelalisib— uncovered