MDT-AP-0130
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- overall_survival_months
- 52.67999999999999
- os_event
- true
- age_years
- 11
- sex
- M
- new_clusters
- C3
- umap1_2d
- 4.549408914
- umap2_2d
- 5.190484377
- umap1_3d
- 2.798249498
- umap2_3d
- -1.920014093
- umap3_3d
- -3.531490867
- dataset
- Med-Taylor
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-0222 | Med | Medulloblastoma | 0.927 |
| 2 | 302722c6-102e-4b1b-845e-78920380e337 | — | — | 0.883 |
| 3 | BS_Q13FQ8FV | Diffuse intrinsic pontine glioma | — | 0.878 |
| 4 | d333233b-e431-462b-ae35-c3b4c6ab3a40 | — | — | 0.877 |
| 5 | BS_9CA93S6D | Diffuse intrinsic pontine glioma | — | 0.867 |
| 6 | MDT-AP-0179 | Med | Medulloblastoma | 0.860 |
| 7 | TCGA-GU-A42R-01A-11R-A23N-07 | — | — | 0.848 |
| 8 | MDT-AP-0376 | Med | Medulloblastoma | 0.847 |
| 9 | MDT-AP-0847 | Med | Medulloblastoma | 0.844 |
| 10 | MBCProject_0719_T1_RNA | — | A | 0.843 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.380 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.270 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.200 | Temsirolimus | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.180 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.080 | Remibrutinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.070 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.040 | Inavolisib | — uncovered |