Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AR-A1AU-01A-11R-A12P-07

· A

9cb8133d-d6e8-5df3-ad4b-6ffb8950aefb

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
A
subtype
A
overall_survival_months
96
os_event
false

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ESTROGEN_RESPONSE_EARLY+0.480
  • HEDGEHOG_SIGNALING+0.410
  • ESTROGEN_RESPONSE_LATE+0.400
  • HYPOXIA+0.390
  • MYOGENESIS+0.370
  • TNFA_SIGNALING_VIA_NFKB+0.370
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.340
  • UV_RESPONSE_DN+0.330
  • APICAL_JUNCTION+0.300
  • MITOTIC_SPINDLE+0.270

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.430
  • INTERFERON_ALPHA_RESPONSE-0.420
  • OXIDATIVE_PHOSPHORYLATION-0.410
  • INTERFERON_GAMMA_RESPONSE-0.390
  • DNA_REPAIR-0.350
  • E2F_TARGETS-0.340
  • NOTCH_SIGNALING-0.250
  • G2M_CHECKPOINT-0.140
  • MYC_TARGETS_V1-0.120
  • MTORC1_SIGNALING-0.110

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1563e85fb-9532-4d69-a1b5-2bc77f237b77
colon-landscapes@1
0.792
2MNG119
mng-umap@100
0.787
3TCGA-BH-A0W4-01A-11R-A109-07
breast-umap@18
A0.778
4MNG528
mng-umap@100
0.772
5MNG115
mng-umap@100
0.770
6SRR8613758
breast-umap@18
C0.764
720060260.Her2HRpos
breast-umap@18
A0.756
8de751aae-bc7a-4d70-9d06-4417be4facae
melanoma-umap@29
0.751
920030016.LumA
breast-umap@18
B0.745
10SRR8613716
breast-umap@18
C0.738

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ESTROGEN_RESPONSE_EARLY0.480Inavolisib— uncovered
HEDGEHOG_SIGNALING0.410Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.400Idelalisib— uncovered
HYPOXIA0.390Idelalisib— uncovered
MYOGENESIS0.370Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.370Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.340Inavolisib— uncovered
UV_RESPONSE_DN0.330Inavolisib— uncovered
APICAL_JUNCTION0.300Inavolisib— uncovered
MITOTIC_SPINDLE0.270Inavolisib— uncovered
PANCREAS_BETA_CELLS0.250Cobimetinib— uncovered
ADIPOGENESIS0.240Inavolisib— uncovered
ANDROGEN_RESPONSE0.240Inavolisib— uncovered
BILE_ACID_METABOLISM0.230Inavolisib— uncovered
APOPTOSIS0.210Idelalisib— uncovered
TGF_BETA_SIGNALING0.190Inavolisib— uncovered
ANGIOGENESIS0.170Remibrutinib— uncovered
PEROXISOME0.170Idelalisib— uncovered
PROTEIN_SECRETION0.150Remibrutinib— uncovered
XENOBIOTIC_METABOLISM0.140Inavolisib— uncovered