Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-CV-7102-01A-11R-2016-07

9cbb6ced-b0fb-5cb6-8d5f-26e74315061e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.012785388
sex
female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ANGIOGENESIS+0.550
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.550
  • MYOGENESIS+0.530
  • G2M_CHECKPOINT+0.480
  • HEDGEHOG_SIGNALING+0.470
  • E2F_TARGETS+0.460
  • MITOTIC_SPINDLE+0.370
  • APICAL_JUNCTION+0.320
  • PANCREAS_BETA_CELLS+0.310
  • UV_RESPONSE_DN+0.310

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.400
  • TNFA_SIGNALING_VIA_NFKB-0.350
  • INTERFERON_GAMMA_RESPONSE-0.290
  • OXIDATIVE_PHOSPHORYLATION-0.270
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.270
  • CHOLESTEROL_HOMEOSTASIS-0.220
  • UV_RESPONSE_UP-0.220
  • FATTY_ACID_METABOLISM-0.160
  • PEROXISOME-0.100
  • MYC_TARGETS_V2-0.070

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-A8-A07E-01A-11R-A034-07
breast-umap@18
A0.785
2TCGA-BH-A0AV-01A-31R-A115-07
breast-umap@18
E0.756
3DRR168609
bladder-landscape@3
0.754
4TCGA-CN-6022-01A-21R-1686-07
head-neck@1
0.749
5c45adda2-fffe-4add-8148-01ecf35dd855
colon-landscapes@1
0.738
6SRR5903555
lung-landscapes@6
cohortSQ10.736
7TCGA-CR-7365-01A-11R-2016-07
head-neck@1
0.728
8TCGA-AR-A24Q-01A-12R-A169-07
breast-umap@18
E0.720
9TCGA-55-7726-01A-11R-2170-07
lung-landscapes@6
cohortSQ10.720
10R211
bladder-landscape@3
0.713

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 34 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.550Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.550Inavolisib— uncovered
MYOGENESIS0.530Inavolisib— uncovered
G2M_CHECKPOINT0.480Inavolisib— uncovered
HEDGEHOG_SIGNALING0.470Inavolisib— uncovered
E2F_TARGETS0.460Inavolisib— uncovered
MITOTIC_SPINDLE0.370Inavolisib— uncovered
APICAL_JUNCTION0.320Inavolisib— uncovered
PANCREAS_BETA_CELLS0.310Cobimetinib— uncovered
UV_RESPONSE_DN0.310Inavolisib— uncovered
COAGULATION0.280Binimetinib— uncovered
TGF_BETA_SIGNALING0.280Inavolisib— uncovered
KRAS_SIGNALING_UP0.260Inavolisib— uncovered
MYC_TARGETS_V10.210Inavolisib— uncovered
PROTEIN_SECRETION0.170Remibrutinib— uncovered
HYPOXIA0.160Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.160Inavolisib— uncovered
NOTCH_SIGNALING0.140Inavolisib— uncovered
ALLOGRAFT_REJECTION0.130Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.130Inavolisib— uncovered