Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-55-8510-01A-11R-2403-07

· cohortA1

9e656721-1857-5607-a8ba-179214d6d215

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA1
subtype
cohortA1
age_years
55

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8392886
lung-landscapes@6
cohortA10.952
2TCGA-55-8619-01A-11R-2403-07
lung-landscapes@6
cohortA10.943
3SRR598894
brain-umap@2
GTEX0.939
4SRR6013478
lung-landscapes@6
cohortMD20.931
5TCGA-38-A44F-01A-11R-A24H-07
lung-landscapes@6
cohortA10.930
6SRR1394297
brain-umap@2
GTEX0.930
7SRR1331289
brain-umap@2
GTEX0.930
8SRR1468141
brain-umap@2
GTEX0.930
9TCGA-86-8671-01A-11R-2403-07
lung-landscapes@6
cohortMD20.929
10TCGA-99-AA5R-01A-11R-A39D-07
lung-landscapes@6
cohortA10.927

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.460Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.450Inavolisib— uncovered
COAGULATION0.400Binimetinib— uncovered
INFLAMMATORY_RESPONSE0.390Idelalisib— uncovered
KRAS_SIGNALING_UP0.370Inavolisib— uncovered
MYOGENESIS0.360Inavolisib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.330Idelalisib— uncovered
KRAS_SIGNALING_DN0.290Remibrutinib— uncovered
APICAL_JUNCTION0.280Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.280Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.270Inavolisib— uncovered
ANGIOGENESIS0.250Remibrutinib— uncovered
XENOBIOTIC_METABOLISM0.230Inavolisib— uncovered
BILE_ACID_METABOLISM0.190Inavolisib— uncovered
IL2_STAT5_SIGNALING0.170Idelalisib— uncovered
APICAL_SURFACE0.160Temsirolimus— uncovered
ESTROGEN_RESPONSE_EARLY0.070Inavolisib— uncovered
APOPTOSIS0.060Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.050Inavolisib— uncovered