Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · lung-landscapes@6

C3N-00959

— · cohortA1

9f603a60-81c8-5e3e-9f24-f62cb7b9ea6e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
cohortA1
subtype
cohortA1
age_years
66.69678303

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • BILE_ACID_METABOLISM+0.310
  • PANCREAS_BETA_CELLS+0.310
  • TGF_BETA_SIGNALING+0.310
  • NOTCH_SIGNALING+0.280
  • ANDROGEN_RESPONSE+0.250
  • CHOLESTEROL_HOMEOSTASIS+0.240
  • ESTROGEN_RESPONSE_EARLY+0.230
  • COAGULATION+0.210
  • FATTY_ACID_METABOLISM+0.210
  • ADIPOGENESIS+0.190

Top 10 suppressed

  • E2F_TARGETS-0.600
  • G2M_CHECKPOINT-0.540
  • MYC_TARGETS_V2-0.430
  • MTORC1_SIGNALING-0.350
  • MYC_TARGETS_V1-0.350
  • UNFOLDED_PROTEIN_RESPONSE-0.320
  • ANGIOGENESIS-0.280
  • INTERFERON_GAMMA_RESPONSE-0.270
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.260
  • MITOTIC_SPINDLE-0.260

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C3L-03679
lung-landscapes@6
—cohortA10.836
2TCGA-AC-A2FG-01A-11R-A17B-07
breast-umap@18
—A0.827
3SRR8518290
breast-umap@18
—F0.822
4C3L-00368
lung-landscapes@6
—cohortA10.818
5TCGA-BH-A0BM-01A-11R-A056-07
breast-umap@18
—A0.812
6BS_CGB2WS2A
brain-umap@2
pilocytic astrocytoma—0.806
7TCGA-44-6146-01A-11R-1755-07
lung-landscapes@6
—cohortA10.805
8TCGA-44-6776-01A-11R-1858-07
lung-landscapes@6
—cohortA20.796
9TCGA-97-7547-01A-11R-2039-07
lung-landscapes@6
—cohortA10.795
10SRR8518452
breast-umap@18
—A0.793

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
BILE_ACID_METABOLISM0.310Inavolisib— uncovered
PANCREAS_BETA_CELLS0.310Cobimetinib— uncovered
TGF_BETA_SIGNALING0.310Inavolisib— uncovered
NOTCH_SIGNALING0.280Inavolisib— uncovered
ANDROGEN_RESPONSE0.250Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.240Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.230Inavolisib— uncovered
COAGULATION0.210Binimetinib— uncovered
FATTY_ACID_METABOLISM0.210Inavolisib— uncovered
ADIPOGENESIS0.190Inavolisib— uncovered
PEROXISOME0.180Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.180Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.160Idelalisib— uncovered
KRAS_SIGNALING_UP0.160Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.160Inavolisib— uncovered
APOPTOSIS0.150Idelalisib— uncovered
PROTEIN_SECRETION0.150Remibrutinib— uncovered
P53_PATHWAY0.120Idelalisib— uncovered
UV_RESPONSE_DN0.120Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.110Remibrutinib— uncovered