SRR817258
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MITOTIC_SPINDLE+0.195
- PI3K_AKT_MTOR_SIGNALING+0.174
- DNA_REPAIR+0.143
- HEME_METABOLISM+0.075
- PROTEIN_SECRETION+0.071
- UNFOLDED_PROTEIN_RESPONSE+0.062
- G2M_CHECKPOINT+0.010
- MYC_TARGETS_V1+0.010
- MYC_TARGETS_V2+0.010
- KRAS_SIGNALING_DN+0.008
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.555
- TNFA_SIGNALING_VIA_NFKB-0.499
- INTERFERON_GAMMA_RESPONSE-0.495
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.494
- ANGIOGENESIS-0.493
- INFLAMMATORY_RESPONSE-0.478
- KRAS_SIGNALING_UP-0.468
- COAGULATION-0.446
- ALLOGRAFT_REJECTION-0.404
- IL6_JAK_STAT3_SIGNALING-0.404
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1355061 | GTEX | — | 0.974 |
| 2 | SRR657915 | GTEX | — | 0.974 |
| 3 | SRR820468 | GTEX | — | 0.974 |
| 4 | SRR1434782 | GTEX | — | 0.972 |
| 5 | SRR816292 | GTEX | — | 0.971 |
| 6 | SRR1475737 | GTEX | — | 0.970 |
| 7 | SRR1080927 | GTEX | — | 0.970 |
| 8 | SRR817190 | GTEX | — | 0.969 |
| 9 | SRR1476632 | GTEX | — | 0.967 |
| 10 | SRR1490382 | GTEX | — | 0.966 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MITOTIC_SPINDLE | 0.195 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.174 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.143 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.075 | Temsirolimus | — uncovered |
| PROTEIN_SECRETION | 0.071 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.062 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.010 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.010 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.010 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.008 | Remibrutinib | — uncovered |