62504_S126

— · cohortA1

a22e19a0-2eba-508e-945d-d01ed4de6914

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortA1
subtype: cohortA1

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	MNG827 mng-umap@100	—	—	0.740
2	MNG865 mng-umap@100	—	—	0.730
3	30fdca7b-ecb1-4096-b2d2-41831f283ae1 colon-landscapes@1	—	—	0.715
4	C3L-00973 lung-landscapes@6	—	cohortA1	0.714
5	R187 bladder-landscape@3	—	—	0.708
6	MNG311 mng-umap@100	—	—	0.707
7	TCGA-D6-6515-01A-21R-1873-07 head-neck@1	—	—	0.702
8	TCGA-44-3918-01A-01R-1107-07 lung-landscapes@6	—	cohortA1	0.702
9	C3N-01488 lung-landscapes@6	—	cohortA1	0.700
10	SRR8518332 breast-umap@18	—	D	0.695

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
INTERFERON_ALPHA_RESPONSE	0.570	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.510	Idelalisib	— uncovered
ALLOGRAFT_REJECTION	0.320	Idelalisib	— uncovered
PROTEIN_SECRETION	0.290	Remibrutinib	— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION	0.200	Inavolisib	— uncovered
DNA_REPAIR	0.190	Idelalisib	— uncovered
KRAS_SIGNALING_UP	0.180	Inavolisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.180	Inavolisib	— uncovered
COMPLEMENT	0.170	Inavolisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.150	Inavolisib	— uncovered
APICAL_JUNCTION	0.140	Inavolisib	— uncovered
NOTCH_SIGNALING	0.090	Inavolisib	— uncovered
HEDGEHOG_SIGNALING	0.080	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.080	Remibrutinib	— uncovered
APOPTOSIS	0.070	Idelalisib	— uncovered
COAGULATION	0.060	Binimetinib	— uncovered
APICAL_SURFACE	0.050	Temsirolimus	— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY	0.050	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.040	Idelalisib	— uncovered
OXIDATIVE_PHOSPHORYLATION	0.040	Remibrutinib	— uncovered