Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-P3-A6T7-01A-11R-A34R-07

a32e68f4-7328-5b02-88ae-85bcd1d5d553

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.111187215
sex
male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.530
  • MYC_TARGETS_V1+0.410
  • CHOLESTEROL_HOMEOSTASIS+0.400
  • INTERFERON_GAMMA_RESPONSE+0.380
  • MYC_TARGETS_V2+0.380
  • OXIDATIVE_PHOSPHORYLATION+0.300
  • TNFA_SIGNALING_VIA_NFKB+0.290
  • NOTCH_SIGNALING+0.280
  • MTORC1_SIGNALING+0.260
  • ESTROGEN_RESPONSE_LATE+0.250

Top 10 suppressed

  • MYOGENESIS-0.220
  • PROTEIN_SECRETION-0.160
  • ANGIOGENESIS-0.130
  • HEDGEHOG_SIGNALING-0.130
  • UV_RESPONSE_DN-0.120
  • MITOTIC_SPINDLE-0.110
  • WNT_BETA_CATENIN_SIGNALING-0.110
  • ALLOGRAFT_REJECTION-0.100
  • PANCREAS_BETA_CELLS-0.100
  • KRAS_SIGNALING_UP-0.080

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-CV-7099-01A-41R-2016-07
head-neck@1
0.809
2TCGA-MT-A51W-01A-21R-A266-07
head-neck@1
0.794
3A0396799-AB5C-401F-81FF-7C829A3CF1E4
brain-umap@2
0.780
4TCGA-E2-A14Y-01A-21R-A12D-07
breast-umap@18
E0.776
56794CB9F-5326-4F57-B2E2-5D877C03F5D4
brain-umap@2
0.764
6SRR8942992
bladder-landscape@3
0.762
7SRR8942975
bladder-landscape@3
0.762
8TCGA-BA-A6DD-01A-12R-A31N-07
head-neck@1
0.762
9SRR35579811
breast-umap@18
B0.757
10C3N-03425
lung-landscapes@6
cohortSQ10.752

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.530Inavolisib— uncovered
MYC_TARGETS_V10.410Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.400Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.380Idelalisib— uncovered
MYC_TARGETS_V20.380Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.300Remibrutinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.290Inavolisib— uncovered
NOTCH_SIGNALING0.280Inavolisib— uncovered
MTORC1_SIGNALING0.260Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.250Idelalisib— uncovered
HYPOXIA0.250Idelalisib— uncovered
COAGULATION0.220Binimetinib— uncovered
GLYCOLYSIS0.210Inavolisib— uncovered
UV_RESPONSE_UP0.210Idelalisib— uncovered
TGF_BETA_SIGNALING0.200Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.200Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.200Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.180Inavolisib— uncovered
G2M_CHECKPOINT0.170Inavolisib— uncovered
P53_PATHWAY0.170Idelalisib— uncovered