Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_DV86M0Y7

pilocytic astrocytoma

a3e19451-7723-58d6-8e27-3266cc632601

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
pilocytic astrocytoma
cancer_type_detailed
subtype
cancer_type
pilocytic astrocytoma
age_years
12.693
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_1ZVXF5FE
brain-umap@2
pilocytic astrocytoma0.919
2TCGA-97-A4M2-01A-12R-A24X-07
lung-landscapes@6
cohortA10.904
3BS_Y7F9E2E9
brain-umap@2
low-grade glioma0.898
4BS_21RE8W46
brain-umap@2
pilocytic astrocytoma0.897
5TCGA-55-7728-01A-11R-2187-07
lung-landscapes@6
cohortA10.892
6ERR2598332
medullo-epn-umap@date-based
fetalfetal0.892
7TCGA-J2-A4AE-01A-21R-A24H-07
lung-landscapes@6
cohortA10.890
8s0099982
melanoma-umap@29
0.889
9MDT-AP-2047
medullo-epn-umap@date-based
MedMedulloblastoma0.887
10MDT-AP-0813
medullo-epn-umap@date-based
MedMedulloblastoma0.887

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 21 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.332Remibrutinib— uncovered
MYOGENESIS0.316Inavolisib— uncovered
ALLOGRAFT_REJECTION0.219Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.216Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.190Idelalisib— uncovered
BILE_ACID_METABOLISM0.171Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.155Inavolisib— uncovered
COMPLEMENT0.154Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.141Inavolisib— uncovered
KRAS_SIGNALING_UP0.141Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.127Inavolisib— uncovered
APICAL_SURFACE0.125Temsirolimus— uncovered
INTERFERON_ALPHA_RESPONSE0.102Inavolisib— uncovered
IL2_STAT5_SIGNALING0.095Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.092Inavolisib— uncovered
COAGULATION0.087Binimetinib— uncovered
PANCREAS_BETA_CELLS0.085Cobimetinib— uncovered
P53_PATHWAY0.068Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.049Idelalisib— uncovered
APICAL_JUNCTION0.030Inavolisib— uncovered