Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

5d2d4263-d17d-424f-9c82-bf665306d71f

a5a36d8b-3720-55ab-966c-3af73f39de00

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
55.2443531827515

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C3N-04155
lung-landscapes@6
cohortSQ20.907
2a7d1fe23-5255-4daa-a6a9-fe2f67491323
colon-landscapes@1
0.907
3TCGA-33-AAS8-01A-11R-A405-07
lung-landscapes@6
cohortSQ20.900
4TCGA-LA-A446-01A-21R-A24Z-07
lung-landscapes@6
cohortSQ20.899
5e235012b-4b29-478a-abad-6a70cd949cfa
colon-landscapes@1
0.897
6TCGA-77-8154-01A-11R-2247-07
lung-landscapes@6
cohortSQ10.890
7TCGA-58-8392-01A-11R-2326-07
lung-landscapes@6
cohortSQ20.883
8TCGA-94-8490-01A-11R-2326-07
lung-landscapes@6
cohortSQ20.880
9be971158-ffec-4142-afc3-4ea3164fa86c
colon-landscapes@1
0.877
10TCGA-58-A46N-01A-11R-A24H-07
lung-landscapes@6
cohortSQ20.875

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.540Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.400Inavolisib— uncovered
E2F_TARGETS0.390Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.380Idelalisib— uncovered
G2M_CHECKPOINT0.330Inavolisib— uncovered
MYC_TARGETS_V10.320Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.220Remibrutinib— uncovered
DNA_REPAIR0.210Idelalisib— uncovered
MITOTIC_SPINDLE0.210Inavolisib— uncovered
PEROXISOME0.200Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.180Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.170Inavolisib— uncovered
MTORC1_SIGNALING0.160Inavolisib— uncovered
NOTCH_SIGNALING0.150Inavolisib— uncovered
P53_PATHWAY0.150Idelalisib— uncovered
UV_RESPONSE_UP0.150Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.140Inavolisib— uncovered
FATTY_ACID_METABOLISM0.140Inavolisib— uncovered
HEDGEHOG_SIGNALING0.120Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.110Idelalisib— uncovered