Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

MBCProject_3632_T1_RNA

· B

a6c6e39c-1522-509b-9725-aef6b86a978f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-A2-A0CP-01A-11R-A034-07
breast-umap@18
A0.875
257583139-d2d3-4b97-a616-aa96058d4682
melanoma-umap@29
0.858
3SRR493947
lung-landscapes@6
cohortA10.850
4MBCProject_0988_T1_RNA
breast-umap@18
B0.846
5TCGA-3C-AALK-01A-11R-A41B-07
breast-umap@18
A0.841
6TCGA-E2-A1IF-01A-11R-A144-07
breast-umap@18
A0.841
7SRR35579814
breast-umap@18
A0.838
869d9a82b-5c37-45bd-a1cf-ffe1392e84fc
melanoma-umap@29
0.837
944f9e45d-d779-4865-8f10-d085d5d25447
melanoma-umap@29
0.837
10MBCProject_3672_T1_RNA
breast-umap@18
B0.826

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.390Inavolisib— uncovered
ANGIOGENESIS0.310Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.260Inavolisib— uncovered
MYOGENESIS0.260Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.260Inavolisib— uncovered
COAGULATION0.250Binimetinib— uncovered
ESTROGEN_RESPONSE_LATE0.230Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.190Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.190Inavolisib— uncovered
KRAS_SIGNALING_DN0.180Remibrutinib— uncovered
P53_PATHWAY0.160Idelalisib— uncovered
APICAL_JUNCTION0.140Inavolisib— uncovered
APICAL_SURFACE0.140Temsirolimus— uncovered
XENOBIOTIC_METABOLISM0.140Inavolisib— uncovered
HYPOXIA0.120Idelalisib— uncovered
NOTCH_SIGNALING0.120Inavolisib— uncovered
APOPTOSIS0.100Idelalisib— uncovered
FATTY_ACID_METABOLISM0.100Inavolisib— uncovered
IL2_STAT5_SIGNALING0.100Idelalisib— uncovered
UV_RESPONSE_UP0.100Idelalisib— uncovered