Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

44f9e45d-d779-4865-8f10-d085d5d25447

c7139f14-35d1-563e-9256-ba6d9f5bbee4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1c0054cf0-8f4b-47b6-a8fc-63a1fd36bcc7
melanoma-umap@29
0.922
2290b89f5-2a44-424b-b77d-a190dcb93e07
colon-landscapes@1
0.872
3399cd50c-1439-48a4-ba3b-a0782b2b7b62
melanoma-umap@29
0.842
440b92a76-f324-4cdd-8209-517d021acd47
melanoma-umap@29
0.841
5MBCProject_3632_T1_RNA
breast-umap@18
B0.837
6SRR4195687
colon-landscapes@1
0.832
7SAMN03290910
melanoma-umap@29
0.831
857583139-d2d3-4b97-a616-aa96058d4682
melanoma-umap@29
0.823
9SAMN03290888
melanoma-umap@29
0.823
1080bea63b-bc3a-4999-8c11-a35c92183cd7
colon-landscapes@1
0.822

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
CHOLESTEROL_HOMEOSTASIS0.500Remibrutinib— uncovered
KRAS_SIGNALING_DN0.400Remibrutinib— uncovered
MYOGENESIS0.400Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.400Inavolisib— uncovered
ANGIOGENESIS0.300Remibrutinib— uncovered
APICAL_JUNCTION0.300Inavolisib— uncovered
APICAL_SURFACE0.300Temsirolimus— uncovered
COAGULATION0.300Binimetinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.300Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.300Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.300Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.300Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.200Inavolisib— uncovered
HEDGEHOG_SIGNALING0.200Inavolisib— uncovered
HYPOXIA0.200Idelalisib— uncovered
ADIPOGENESIS0.100Inavolisib— uncovered
APOPTOSIS0.100Idelalisib— uncovered
BILE_ACID_METABOLISM0.100Inavolisib— uncovered
DNA_REPAIR0.100Idelalisib— uncovered
FATTY_ACID_METABOLISM0.100Inavolisib— uncovered