SRR5088854
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.400
- INTERFERON_GAMMA_RESPONSE+0.200
- MYC_TARGETS_V2+0.200
- OXIDATIVE_PHOSPHORYLATION+0.200
- DNA_REPAIR+0.100
- MYC_TARGETS_V1+0.100
- ADIPOGENESIS+0.000
- ALLOGRAFT_REJECTION+0.000
- KRAS_SIGNALING_DN+0.000
- PANCREAS_BETA_CELLS+0.000
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- ANGIOGENESIS-0.400
- APICAL_JUNCTION-0.400
- E2F_TARGETS-0.400
- G2M_CHECKPOINT-0.400
- NOTCH_SIGNALING-0.400
- TGF_BETA_SIGNALING-0.400
- TNFA_SIGNALING_VIA_NFKB-0.400
- APICAL_SURFACE-0.300
- COAGULATION-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-ZF-A9R5-01A-12R-A42T-07 | — | — | 0.900 |
| 2 | 0a4a9b5b-90d9-4789-af04-f931433808c1 | — | — | 0.835 |
| 3 | 6ca5eb09-d104-4305-b3ec-4d6e8a0c2850 | — | — | 0.827 |
| 4 | TCGA-XF-AAN1-01A-31R-A42T-07 | — | — | 0.810 |
| 5 | 20040020.LumA | — | B | 0.807 |
| 6 | TCGA-62-A472-01A-11R-A24H-07 | — | cohortA1 | 0.800 |
| 7 | b6a7e87e-2674-4a48-a3c2-c8a9806762b5 | — | — | 0.794 |
| 8 | SAMN03290916 | — | — | 0.790 |
| 9 | SRR10900001 | — | — | 0.789 |
| 10 | s0095165 | — | — | 0.786 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.400 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.200 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.200 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.200 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.100 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.100 | Inavolisib | — uncovered |