TCGA-ZF-A9R5-01A-12R-A42T-07
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- overall_survival_months
- 35.80814717
- os_event
- false
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.410
- OXIDATIVE_PHOSPHORYLATION+0.240
- MYC_TARGETS_V2+0.060
- DNA_REPAIR+0.010
- PROTEIN_SECRETION+0.000
- BILE_ACID_METABOLISM-0.010
- INTERFERON_GAMMA_RESPONSE-0.050
- HEME_METABOLISM-0.060
- MYC_TARGETS_V1-0.060
- PANCREAS_BETA_CELLS-0.090
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.630
- E2F_TARGETS-0.580
- TNFA_SIGNALING_VIA_NFKB-0.510
- CHOLESTEROL_HOMEOSTASIS-0.480
- ANGIOGENESIS-0.470
- G2M_CHECKPOINT-0.470
- COAGULATION-0.460
- INFLAMMATORY_RESPONSE-0.450
- HYPOXIA-0.420
- MTORC1_SIGNALING-0.420
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR5088854 | — | — | 0.900 |
| 2 | R247 | — | — | 0.896 |
| 3 | AUR-AEPZ-TTM1-A-1-1-R-A742-41 | — | B | 0.873 |
| 4 | SAMN03290916 | — | — | 0.871 |
| 5 | SRR2755094 | — | — | 0.845 |
| 6 | b6a7e87e-2674-4a48-a3c2-c8a9806762b5 | — | — | 0.845 |
| 7 | TCGA-E7-A678-01A-11R-A30C-07 | — | — | 0.843 |
| 8 | SRR650134 | — | — | 0.840 |
| 9 | sclc283559_S82.txt | — | cohortSC | 0.837 |
| 10 | SAMN03290914 | — | — | 0.835 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.410 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.240 | Remibrutinib | — uncovered |
| MYC_TARGETS_V2 | 0.060 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.010 | Idelalisib | — uncovered |