SRR2016932

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a9226dea-13bd-5a28-bb75-baeef6d07c7a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —
sex: male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

BILE_ACID_METABOLISM+0.220
KRAS_SIGNALING_DN+0.170
ALLOGRAFT_REJECTION+0.110
WNT_BETA_CATENIN_SIGNALING+0.050
SPERMATOGENESIS+0.010
MYOGENESIS+0.000
APICAL_SURFACE-0.010
ESTROGEN_RESPONSE_EARLY-0.010
PEROXISOME-0.030
HEDGEHOG_SIGNALING-0.060

Top 10 suppressed

MYC_TARGETS_V1-0.670
E2F_TARGETS-0.650
MYC_TARGETS_V2-0.650
G2M_CHECKPOINT-0.630
MTORC1_SIGNALING-0.550
OXIDATIVE_PHOSPHORYLATION-0.520
INTERFERON_ALPHA_RESPONSE-0.480
UNFOLDED_PROTEIN_RESPONSE-0.470
EPITHELIAL_MESENCHYMAL_TRANSITION-0.460
GLYCOLYSIS-0.450

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-55-A4DG-01A-11R-A24H-07 lung-landscapes@6	—	cohortA1	0.945
2	b03ebc32.a177.44c7.8b02.fcd6560712f2 lung-landscapes@6	—	cohortA1	0.925
3	SRR2016937 head-neck@1	—	—	0.913
4	C3N-02950 lung-landscapes@6	—	cohortA1	0.908
5	C3N-01799 lung-landscapes@6	—	cohortA1	0.907
6	ULC0589T_S77 lung-landscapes@6	—	cohortA1	0.901
7	SRR1313099 breast-umap@18	—	A	0.898
8	BS_C80S5N37 medullo-epn-umap@date-based	EPN	EPN Tumor	0.898
9	SJEPD030_D.RNA-Seq medullo-epn-umap@date-based	EPN	Posterior Fossa EPN	0.896
10	TCGA-CU-A3YL-01A-11R-A22U-07 bladder-landscape@3	—	—	0.893

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 5 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
BILE_ACID_METABOLISM	0.220	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.170	Remibrutinib	— uncovered
ALLOGRAFT_REJECTION	0.110	Idelalisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.050	Inavolisib	— uncovered
SPERMATOGENESIS	0.010	Inavolisib	— uncovered