SRR1313099
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.230
- ALLOGRAFT_REJECTION+0.150
- BILE_ACID_METABOLISM+0.110
- WNT_BETA_CATENIN_SIGNALING+0.080
- IL6_JAK_STAT3_SIGNALING+0.070
- UV_RESPONSE_DN+0.030
- ADIPOGENESIS+0.010
- XENOBIOTIC_METABOLISM+0.000
- KRAS_SIGNALING_DN-0.010
- KRAS_SIGNALING_UP-0.010
Top 10 suppressed
- E2F_TARGETS-0.700
- MYC_TARGETS_V1-0.660
- G2M_CHECKPOINT-0.650
- MYC_TARGETS_V2-0.630
- MTORC1_SIGNALING-0.570
- UNFOLDED_PROTEIN_RESPONSE-0.480
- GLYCOLYSIS-0.420
- ESTROGEN_RESPONSE_LATE-0.370
- ANDROGEN_RESPONSE-0.350
- MITOTIC_SPINDLE-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1313120 | — | A | 0.924 |
| 2 | SRR2016932 | — | — | 0.898 |
| 3 | TCGA-55-A4DG-01A-11R-A24H-07 | — | cohortA1 | 0.887 |
| 4 | TCGA-NJ-A55A-01A-11R-A262-07 | — | cohortA1 | 0.886 |
| 5 | 20020052.LumA | — | A | 0.871 |
| 6 | s0122234 | — | — | 0.866 |
| 7 | TCGA-97-A4M1-01A-11R-A24X-07 | — | cohortA1 | 0.866 |
| 8 | MNG60 | — | — | 0.865 |
| 9 | TCGA-97-A4M2-01A-12R-A24X-07 | — | cohortA1 | 0.862 |
| 10 | BS_A87NPZAP | Med | Medulloblastoma | 0.854 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.230 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.150 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.110 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.080 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.070 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.030 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.010 | Inavolisib | — uncovered |