e97f9781-5033-40bd-bc5c-7a703ef965b1
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V1+0.500
- MYC_TARGETS_V2+0.400
- E2F_TARGETS+0.300
- OXIDATIVE_PHOSPHORYLATION+0.300
- G2M_CHECKPOINT+0.200
- PANCREAS_BETA_CELLS+0.200
- FATTY_ACID_METABOLISM+0.100
- KRAS_SIGNALING_DN+0.100
- SPERMATOGENESIS+0.100
- ADIPOGENESIS+0.000
Top 10 suppressed
- COAGULATION-0.500
- COMPLEMENT-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- INFLAMMATORY_RESPONSE-0.500
- INTERFERON_ALPHA_RESPONSE-0.500
- INTERFERON_GAMMA_RESPONSE-0.500
- ALLOGRAFT_REJECTION-0.400
- ANGIOGENESIS-0.400
- APOPTOSIS-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR5088911 | — | — | 0.923 |
| 2 | R16 | — | — | 0.912 |
| 3 | BS_ZXYDSBM9 | medulloblastoma | — | 0.910 |
| 4 | C3L-00965 | — | cohortSQ2 | 0.909 |
| 5 | SRR8518243 | — | E | 0.909 |
| 6 | s0112225 | — | — | 0.908 |
| 7 | C3N-02283 | — | cohortMD1 | 0.893 |
| 8 | SRR5088819 | — | — | 0.892 |
| 9 | sclcMAD04148_S54.txt | — | cohortSC | 0.891 |
| 10 | BS_H4B5Y6S0 | medulloblastoma | — | 0.891 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V1 | 0.500 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.400 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.300 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.300 | Remibrutinib | — uncovered |
| G2M_CHECKPOINT | 0.200 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.200 | Cobimetinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.100 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |