Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_MWWZBQ60

high-grade glioma

a979c619-b8dd-54c6-aa67-edb99f9ad3a6

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
high-grade glioma
cancer_type_detailed
subtype
cancer_type
high-grade glioma
overall_survival_months
17.608409986859396
age_years
11.836
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1DRR168559
bladder-landscape@3
0.818
2BS_30VC3R2Q
brain-umap@2
Diffuse intrinsic pontine glioma0.813
3fec205e8-388c-47a2-9400-ec9fe2e0fab1
colon-landscapes@1
0.807
4EPT0578
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.799
5MNG223
mng-umap@100
0.790
6TCGA-CV-6961-01A-21R-1915-07
head-neck@1
0.772
7TCGA-77-7338-01A-11R-2045-07
lung-landscapes@6
cohortSQ20.772
8SRR1313160
breast-umap@18
E0.768
9TCGA-60-2707-01A-01R-0851-07
lung-landscapes@6
cohortSQ10.764
10sclcRT1198_S58.txt
lung-landscapes@6
cohortSC0.763

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 40 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
HYPOXIA0.566Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.426Inavolisib— uncovered
MTORC1_SIGNALING0.344Inavolisib— uncovered
GLYCOLYSIS0.323Inavolisib— uncovered
MITOTIC_SPINDLE0.296Inavolisib— uncovered
COAGULATION0.272Binimetinib— uncovered
MYOGENESIS0.264Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.256Idelalisib— uncovered
ANGIOGENESIS0.247Remibrutinib— uncovered
G2M_CHECKPOINT0.245Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.240Idelalisib— uncovered
NOTCH_SIGNALING0.228Inavolisib— uncovered
COMPLEMENT0.222Inavolisib— uncovered
PANCREAS_BETA_CELLS0.222Cobimetinib— uncovered
KRAS_SIGNALING_UP0.214Inavolisib— uncovered
ADIPOGENESIS0.211Inavolisib— uncovered
HEME_METABOLISM0.196Temsirolimus— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.195Inavolisib— uncovered
P53_PATHWAY0.192Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.190Idelalisib— uncovered