TCGA-44-5644-01A-21R-2039-07
— · cohortA3
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA3
- subtype
- cohortA3
- age_years
- 51
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.510
- SPERMATOGENESIS+0.260
- UNFOLDED_PROTEIN_RESPONSE+0.170
- KRAS_SIGNALING_DN+0.100
- HEDGEHOG_SIGNALING+0.070
- HYPOXIA+0.040
- COAGULATION+0.010
- ANGIOGENESIS-0.030
- E2F_TARGETS-0.040
- PROTEIN_SECRETION-0.050
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.550
- INTERFERON_GAMMA_RESPONSE-0.520
- ALLOGRAFT_REJECTION-0.480
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.470
- CHOLESTEROL_HOMEOSTASIS-0.410
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.390
- APICAL_SURFACE-0.370
- APICAL_JUNCTION-0.360
- P53_PATHWAY-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SAMN03290928 | — | — | 0.865 |
| 2 | SRR12202488 | — | — | 0.864 |
| 3 | C3N-00180 | — | cohortA3 | 0.858 |
| 4 | SRR12696788 | — | — | 0.855 |
| 5 | TCGA-E9-A245-01A-22R-A16F-07 | — | B | 0.842 |
| 6 | BS_W60RQAKK | high-grade glioma | — | 0.833 |
| 7 | SRR12696792 | — | — | 0.831 |
| 8 | sclcD1531109_S55.txt | — | cohortSC | 0.830 |
| 9 | SRR10899984 | — | — | 0.829 |
| 10 | SRR1485892 | GTEX | — | 0.829 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.510 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.260 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.170 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.100 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.070 | Inavolisib | — uncovered |
| HYPOXIA | 0.040 | Idelalisib | — uncovered |
| COAGULATION | 0.010 | Binimetinib | — uncovered |