C3N-00180
— · cohortA3
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA3
- subtype
- cohortA3
- age_years
- 56.46817248
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.280
- WNT_BETA_CATENIN_SIGNALING+0.240
- PANCREAS_BETA_CELLS+0.210
- HEDGEHOG_SIGNALING+0.190
- OXIDATIVE_PHOSPHORYLATION+0.160
- UNFOLDED_PROTEIN_RESPONSE+0.120
- G2M_CHECKPOINT+0.090
- HYPOXIA+0.080
- TGF_BETA_SIGNALING+0.080
- KRAS_SIGNALING_DN+0.010
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.630
- ALLOGRAFT_REJECTION-0.560
- INTERFERON_GAMMA_RESPONSE-0.560
- IL6_JAK_STAT3_SIGNALING-0.530
- INFLAMMATORY_RESPONSE-0.490
- COMPLEMENT-0.400
- IL2_STAT5_SIGNALING-0.360
- APICAL_SURFACE-0.350
- P53_PATHWAY-0.350
- CHOLESTEROL_HOMEOSTASIS-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-44-5644-01A-21R-2039-07 | — | cohortA3 | 0.858 |
| 2 | SRR4195697 | — | — | 0.847 |
| 3 | SRR2016964 | — | — | 0.844 |
| 4 | 204241b7-1e28-43f8-a681-f872b52fa3f8 | — | — | 0.831 |
| 5 | 20130253.TNBC | — | E | 0.825 |
| 6 | SRR8613756 | — | E | 0.818 |
| 7 | BS_QRDT19KS | medulloblastoma | — | 0.817 |
| 8 | SRR1797244 | — | cohortSC | 0.817 |
| 9 | TCGA-CX-7082-01A-11R-2016-07 | — | — | 0.813 |
| 10 | TCGA-3C-AAAU-01A-11R-A41B-07 | — | B | 0.808 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.280 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.240 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.210 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.190 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.160 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.120 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.090 | Inavolisib | — uncovered |
| HYPOXIA | 0.080 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.080 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.010 | Remibrutinib | — uncovered |