486430aa-f745-4353-9e03-6226ac8d9993
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.500
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.400
- FATTY_ACID_METABOLISM+0.300
- GLYCOLYSIS+0.300
- ADIPOGENESIS+0.200
- BILE_ACID_METABOLISM+0.200
- CHOLESTEROL_HOMEOSTASIS+0.200
- PEROXISOME+0.200
- XENOBIOTIC_METABOLISM+0.200
- DNA_REPAIR+0.100
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.500
- ANGIOGENESIS-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- UV_RESPONSE_DN-0.400
- G2M_CHECKPOINT-0.300
- INFLAMMATORY_RESPONSE-0.300
- INTERFERON_GAMMA_RESPONSE-0.300
- KRAS_SIGNALING_UP-0.300
- MITOTIC_SPINDLE-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG908 | — | — | 0.808 |
| 2 | MDT-AP-2103 | Med | Medulloblastoma | 0.807 |
| 3 | SRR1440517 | GTEX | — | 0.806 |
| 4 | TCGA-D8-A1JS-01A-11R-A13Q-07 | — | B | 0.806 |
| 5 | TCGA-B6-A0IB-01A-11R-A034-07 | — | B | 0.804 |
| 6 | SRR25043618 | — | — | 0.803 |
| 7 | SRR1401276 | GTEX | — | 0.802 |
| 8 | TCGA-A7-A3RF-01A-11R-A22K-07 | — | B | 0.801 |
| 9 | SRR1413959 | GTEX | — | 0.800 |
| 10 | TCGA-49-4486-01A-01R-1206-07 | — | cohortA2 | 0.799 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 18 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.500 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.400 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.300 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.300 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.200 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.200 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.200 | Remibrutinib | — uncovered |
| PEROXISOME | 0.200 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.200 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.100 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.100 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |
| KRAS_SIGNALING_DN | 0.100 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.100 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.100 | Cobimetinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.100 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.100 | Idelalisib | — uncovered |