Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-A7-A3RF-01A-11R-A22K-07

· B

ad798086-9e42-52cd-9615-245378d9020e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
14

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.420
  • ADIPOGENESIS+0.210
  • FATTY_ACID_METABOLISM+0.150
  • GLYCOLYSIS+0.150
  • MYOGENESIS+0.150
  • HEME_METABOLISM+0.140
  • BILE_ACID_METABOLISM+0.120
  • HEDGEHOG_SIGNALING+0.110
  • MYC_TARGETS_V2+0.110
  • HYPOXIA+0.100

Top 10 suppressed

  • E2F_TARGETS-0.490
  • ALLOGRAFT_REJECTION-0.460
  • IL6_JAK_STAT3_SIGNALING-0.460
  • G2M_CHECKPOINT-0.450
  • INTERFERON_GAMMA_RESPONSE-0.400
  • INFLAMMATORY_RESPONSE-0.380
  • NOTCH_SIGNALING-0.360
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.320
  • INTERFERON_ALPHA_RESPONSE-0.310
  • TGF_BETA_SIGNALING-0.300

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG1050
mng-umap@100
0.861
2TCGA-LL-A6FP-01A-11R-A31O-07
breast-umap@18
B0.845
3SRR1385124
brain-umap@2
GTEX0.832
4TCGA-B6-A0X4-01A-11R-A109-07
breast-umap@18
B0.825
5SRR1437538
brain-umap@2
GTEX0.820
6SRR8518211
breast-umap@18
C0.816
7MDT-AP-2103
medullo-epn-umap@date-based
MedMedulloblastoma0.813
8SRR1386708
brain-umap@2
GTEX0.812
9TCGA-OL-A6VR-01A-32R-A33J-07
breast-umap@18
B0.810
10TCGA-GM-A2DC-01A-11R-A18M-07
breast-umap@18
B0.804

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.420Remibrutinib— uncovered
ADIPOGENESIS0.210Inavolisib— uncovered
FATTY_ACID_METABOLISM0.150Inavolisib— uncovered
GLYCOLYSIS0.150Inavolisib— uncovered
MYOGENESIS0.150Inavolisib— uncovered
HEME_METABOLISM0.140Temsirolimus— uncovered
BILE_ACID_METABOLISM0.120Inavolisib— uncovered
HEDGEHOG_SIGNALING0.110Inavolisib— uncovered
MYC_TARGETS_V20.110Idelalisib— uncovered
HYPOXIA0.100Idelalisib— uncovered
PEROXISOME0.100Idelalisib— uncovered
DNA_REPAIR0.080Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.070Inavolisib— uncovered
MTORC1_SIGNALING0.060Inavolisib— uncovered
PANCREAS_BETA_CELLS0.050Cobimetinib— uncovered
P53_PATHWAY0.040Idelalisib— uncovered
COAGULATION0.030Binimetinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.030Idelalisib— uncovered
UV_RESPONSE_UP0.030Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.020Remibrutinib— uncovered