Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-S5-A6DX-01A-11R-A31N-07

ae8b6740-97cb-5b46-ab66-ebf8f2f7e917

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
1.839684625
os_event
true
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-LL-A5YL-01A-12R-A29R-07
breast-umap@18
B0.893
2TCGA-E9-A3X8-01A-31R-A22U-07
breast-umap@18
B0.872
3SRR1411024
brain-umap@2
GTEX0.838
4TCGA-OL-A66N-01A-12R-A31O-07
breast-umap@18
B0.832
5TCGA-KQ-A41P-01A-12R-A33J-07
bladder-landscape@3
0.823
6TCGA-XF-A8HF-01A-11R-A36F-07
bladder-landscape@3
0.812
7dc3154b7-6ae4-446a-8a80-91a86c57cefe
melanoma-umap@29
0.804
8SRR5088872
melanoma-umap@29
0.802
9MNG431
mng-umap@100
0.797
10R57
bladder-landscape@3
0.794

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 22 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.350Idelalisib— uncovered
MYOGENESIS0.300Inavolisib— uncovered
COAGULATION0.280Binimetinib— uncovered
KRAS_SIGNALING_DN0.270Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.220Cobimetinib— uncovered
BILE_ACID_METABOLISM0.200Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.190Remibrutinib— uncovered
APICAL_SURFACE0.150Temsirolimus— uncovered
XENOBIOTIC_METABOLISM0.150Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.140Inavolisib— uncovered
SPERMATOGENESIS0.140Inavolisib— uncovered
COMPLEMENT0.130Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.130Idelalisib— uncovered
ANGIOGENESIS0.120Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.120Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.100Remibrutinib— uncovered
ESTROGEN_RESPONSE_LATE0.100Idelalisib— uncovered
KRAS_SIGNALING_UP0.100Inavolisib— uncovered
IL2_STAT5_SIGNALING0.090Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.090Inavolisib— uncovered