Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-DK-AA6Q-01A-11R-A39I-07

b04d451e-ccb7-5fd8-99be-c947a448324f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
13.56767411
os_event
true
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.470
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.420
  • MYC_TARGETS_V2+0.390
  • G2M_CHECKPOINT+0.360
  • INTERFERON_GAMMA_RESPONSE+0.360
  • MTORC1_SIGNALING+0.350
  • APICAL_SURFACE+0.340
  • MYC_TARGETS_V1+0.310
  • E2F_TARGETS+0.300
  • ALLOGRAFT_REJECTION+0.290

Top 10 suppressed

  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.380
  • ANGIOGENESIS-0.230
  • KRAS_SIGNALING_UP-0.200
  • MYOGENESIS-0.160
  • PROTEIN_SECRETION-0.140
  • UV_RESPONSE_DN-0.140
  • ADIPOGENESIS-0.080
  • COAGULATION-0.080
  • HYPOXIA-0.080
  • APOPTOSIS-0.070

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-66-2794-01A-01R-1201-07
lung-landscapes@6
cohortSQ20.845
2TCGA-18-3416-01A-01R-0980-07
lung-landscapes@6
cohortSQ20.796
3ERR2278873
head-neck@1
0.789
4TCGA-CV-7089-01A-11R-2016-07
head-neck@1
0.786
5TCGA-33-4583-01A-01R-1443-07
lung-landscapes@6
cohortSQ20.784
64fc05c1a-63b9-415b-ad42-68b013e21b21
melanoma-umap@29
0.778
7TCGA-K4-A4AC-01A-21R-A26T-07
bladder-landscape@3
0.775
8SRR8518159
breast-umap@18
E0.773
9TCGA-E7-A7XN-01A-11R-A352-07
bladder-landscape@3
0.770
10MNG921
mng-umap@100
0.769

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 31 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.470Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.420Inavolisib— uncovered
MYC_TARGETS_V20.390Idelalisib— uncovered
G2M_CHECKPOINT0.360Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.360Idelalisib— uncovered
MTORC1_SIGNALING0.350Inavolisib— uncovered
APICAL_SURFACE0.340Temsirolimus— uncovered
MYC_TARGETS_V10.310Inavolisib— uncovered
E2F_TARGETS0.300Inavolisib— uncovered
ALLOGRAFT_REJECTION0.290Idelalisib— uncovered
UV_RESPONSE_UP0.240Idelalisib— uncovered
P53_PATHWAY0.220Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.220Inavolisib— uncovered
DNA_REPAIR0.210Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.200Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.160Idelalisib— uncovered
KRAS_SIGNALING_DN0.140Remibrutinib— uncovered
ESTROGEN_RESPONSE_LATE0.130Idelalisib— uncovered
COMPLEMENT0.090Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.090Inavolisib— uncovered