MDT-AP-1341
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- overall_survival_months
- 34.44
- os_event
- false
- age_years
- 7
- sex
- M
- new_clusters
- C1
- umap1_2d
- 4.291767665
- umap2_2d
- 0.699070004
- umap1_3d
- 0.807312232
- umap2_3d
- -3.222192059
- umap3_3d
- -0.344869359
- dataset
- Med-Taylor
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_V9HVBBDW | Med | Medulloblastoma | 0.940 |
| 2 | MDT-AP-1354 | Med | Medulloblastoma | 0.925 |
| 3 | MDT-AP-0038 | Med | Medulloblastoma | 0.916 |
| 4 | SRR1477385 | GTEX | — | 0.909 |
| 5 | MDT-AP-2991 | Med | Medulloblastoma | 0.909 |
| 6 | MDT-AP-1357 | Med | Medulloblastoma | 0.902 |
| 7 | MDT-AP-3207 | Med | Medulloblastoma | 0.902 |
| 8 | BS_GE2RVZE6 | Med | Medulloblastoma | 0.896 |
| 9 | MDT-AP-2017 | Med | Medulloblastoma | 0.896 |
| 10 | SRR1441224 | GTEX | — | 0.893 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.130 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.110 | Temsirolimus | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.110 | Inavolisib | — uncovered |
| PEROXISOME | 0.060 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.030 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.030 | Remibrutinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.020 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.020 | Remibrutinib | — uncovered |