Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

608d8ca8-8eeb-40a1-a95b-57eefcabbdab

b102abc1-e7fa-582f-8a1f-f18b649f0014

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
63

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1AUR-AFUI-TTM1-A-1-0-R-A743-41
breast-umap@18
C0.870
2ad16ffcf-fd80-4008-9309-c4fe1e757507
colon-landscapes@1
0.860
349df6599-2159-457c-a94f-980cab788dbf
colon-landscapes@1
0.856
4f5174c29-918d-4ad9-bd44-c94463396414
colon-landscapes@1
0.852
5BS_49FQXT2E
brain-umap@2
high-grade glioma0.850
6TCGA-33-4589-01A-01R-1443-07
lung-landscapes@6
cohortSQ10.848
7AUR-AFR2-TTP1-A-1-1-R-A742-41
breast-umap@18
C0.846
8TCGA-35-4122-01A-01R-1107-07
lung-landscapes@6
cohortA10.843
9SRR8518165
breast-umap@18
C0.837
103fa3af13-58f0-4c5b-b009-f6f936fb07b5
colon-landscapes@1
0.836

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 37 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.570Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.540Idelalisib— uncovered
ALLOGRAFT_REJECTION0.520Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.490Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.400Idelalisib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.330Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.300Inavolisib— uncovered
MTORC1_SIGNALING0.300Inavolisib— uncovered
E2F_TARGETS0.280Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.240Inavolisib— uncovered
FATTY_ACID_METABOLISM0.230Inavolisib— uncovered
APICAL_SURFACE0.220Temsirolimus— uncovered
KRAS_SIGNALING_UP0.220Inavolisib— uncovered
ANGIOGENESIS0.210Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.210Idelalisib— uncovered
SPERMATOGENESIS0.200Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.190Remibrutinib— uncovered
DNA_REPAIR0.160Idelalisib— uncovered
APOPTOSIS0.150Idelalisib— uncovered