Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BH-A0BT-01A-11R-A12P-07

· B

b2b9993b-1a5f-59da-a13d-275a8349197c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
79

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-BH-A6R8-01A-21R-A33J-07
breast-umap@18
B0.798
2TCGA-GC-A6I3-01A-11R-A31N-07
bladder-landscape@3
0.773
3SRR2016951
head-neck@1
0.772
4MNG930
mng-umap@100
0.754
5SRR2660032
melanoma-umap@29
0.752
6TCGA-OL-A66H-01A-11R-A29R-07
breast-umap@18
B0.751
7TCGA-LL-A5YN-01A-11R-A28M-07
breast-umap@18
B0.748
8edef6762-dd96-4284-81e6-2e128af287fa
melanoma-umap@29
0.745
9ERR2278869
head-neck@1
0.740
10TCGA-64-5778-01A-01R-1628-07
lung-landscapes@6
cohortA10.739

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.580Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.400Idelalisib— uncovered
MYC_TARGETS_V20.390Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.250Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.230Inavolisib— uncovered
ALLOGRAFT_REJECTION0.130Idelalisib— uncovered
COAGULATION0.130Binimetinib— uncovered
DNA_REPAIR0.130Idelalisib— uncovered
KRAS_SIGNALING_DN0.130Remibrutinib— uncovered
ESTROGEN_RESPONSE_LATE0.120Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.100Inavolisib— uncovered
PEROXISOME0.100Idelalisib— uncovered
ADIPOGENESIS0.080Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.080Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.070Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.060Cobimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.050Inavolisib— uncovered
BILE_ACID_METABOLISM0.040Inavolisib— uncovered
APICAL_SURFACE0.020Temsirolimus— uncovered