Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-GC-A6I3-01A-11R-A31N-07

b40ab637-f5b8-59c8-9059-22a133773565

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0
os_event
false
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.350
  • ALLOGRAFT_REJECTION+0.320
  • OXIDATIVE_PHOSPHORYLATION+0.300
  • INTERFERON_ALPHA_RESPONSE+0.240
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.220
  • PANCREAS_BETA_CELLS+0.210
  • DNA_REPAIR+0.190
  • INTERFERON_GAMMA_RESPONSE+0.180
  • MYC_TARGETS_V1+0.120
  • APICAL_SURFACE+0.110

Top 10 suppressed

  • TGF_BETA_SIGNALING-0.550
  • PROTEIN_SECRETION-0.480
  • UV_RESPONSE_DN-0.480
  • MITOTIC_SPINDLE-0.450
  • ANDROGEN_RESPONSE-0.430
  • G2M_CHECKPOINT-0.370
  • WNT_BETA_CATENIN_SIGNALING-0.360
  • TNFA_SIGNALING_VIA_NFKB-0.340
  • ESTROGEN_RESPONSE_EARLY-0.300
  • ANGIOGENESIS-0.290

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-GD-A6C6-01A-21R-A31N-07
bladder-landscape@3
0.824
254f66d7c-b022-4df2-830d-48d55791c80e
melanoma-umap@29
0.802
3TCGA-MT-A67A-01A-11R-A30B-07
head-neck@1
0.788
4BS_TNRHHYNC
medullo-epn-umap@date-based
EPNEPN Tumor0.787
5TCGA-BH-A0BT-01A-11R-A12P-07
breast-umap@18
B0.773
6TCGA-49-AAQV-01A-11R-A39D-07
lung-landscapes@6
cohortA10.772
7TCGA-GU-A763-01A-11R-A32O-07
bladder-landscape@3
0.767
8TCGA-TN-A7HL-01A-11R-A34R-07
head-neck@1
0.766
95e2bb136-9a8b-4481-9394-d7eff1793f97
melanoma-umap@29
0.765
10TCGA-E2-A10C-01A-21R-A10J-07
breast-umap@18
B0.763

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.350Idelalisib— uncovered
ALLOGRAFT_REJECTION0.320Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.300Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.240Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.220Inavolisib— uncovered
PANCREAS_BETA_CELLS0.210Cobimetinib— uncovered
DNA_REPAIR0.190Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.180Idelalisib— uncovered
MYC_TARGETS_V10.120Inavolisib— uncovered
APICAL_SURFACE0.110Temsirolimus— uncovered
SPERMATOGENESIS0.100Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.080Inavolisib— uncovered
BILE_ACID_METABOLISM0.060Inavolisib— uncovered
FATTY_ACID_METABOLISM0.060Inavolisib— uncovered
KRAS_SIGNALING_DN0.050Remibrutinib— uncovered
COAGULATION0.020Binimetinib— uncovered
IL2_STAT5_SIGNALING0.020Idelalisib— uncovered