sclc2388_S39.txt

— · cohortMD2

b3c419ae-94a5-5d95-adcc-60e91c2c7d1a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortMD2
subtype: cohortMD2

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant

#	Sample	Cancer type	Subtype	cos similarity
1	BS_6NTXGQAC brain-umap@2	Ganglioglioma	—	0.911
2	ERR2598319 medullo-epn-umap@date-based	fetal	fetal	0.903
3	MDT-AP-0410 medullo-epn-umap@date-based	Med	Medulloblastoma	0.900
4	MDT-AP-1254 medullo-epn-umap@date-based	Med	Medulloblastoma	0.892
5	ERR2598312 medullo-epn-umap@date-based	fetal	fetal	0.890
6	SAMN03290935 melanoma-umap@29	—	—	0.889
7	SRR2774182 melanoma-umap@29	—	—	0.885
8	MDT-AP-0484 medullo-epn-umap@date-based	Med	Medulloblastoma	0.885
9	SJEPD037_R.RNA-Seq medullo-epn-umap@date-based	EPN	Posterior Fossa EPN	0.885
10	SRR1431345 brain-umap@2	GTEX	—	0.884

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 34 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION	0.470	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.430	Cobimetinib	— uncovered
COAGULATION	0.420	Binimetinib	— uncovered
INFLAMMATORY_RESPONSE	0.420	Idelalisib	— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY	0.420	Inavolisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.370	Inavolisib	— uncovered
ALLOGRAFT_REJECTION	0.360	Idelalisib	— uncovered
XENOBIOTIC_METABOLISM	0.360	Inavolisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.340	Inavolisib	— uncovered
COMPLEMENT	0.330	Inavolisib	— uncovered
KRAS_SIGNALING_UP	0.330	Inavolisib	— uncovered
ANGIOGENESIS	0.320	Remibrutinib	— uncovered
MYOGENESIS	0.290	Inavolisib	— uncovered
IL2_STAT5_SIGNALING	0.270	Idelalisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.270	Idelalisib	— uncovered
CHOLESTEROL_HOMEOSTASIS	0.230	Remibrutinib	— uncovered
FATTY_ACID_METABOLISM	0.230	Inavolisib	— uncovered
HYPOXIA	0.230	Idelalisib	— uncovered
APICAL_JUNCTION	0.210	Inavolisib	— uncovered
ADIPOGENESIS	0.200	Inavolisib	— uncovered