Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AN-A0FV-01A-11R-A00Z-07

· C

b60cb6e6-efcb-5c37-84de-135a01ff7b18

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C
overall_survival_months
0
os_event
false

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.330
  • MTORC1_SIGNALING+0.310
  • ANGIOGENESIS+0.300
  • GLYCOLYSIS+0.260
  • CHOLESTEROL_HOMEOSTASIS+0.250
  • PROTEIN_SECRETION+0.240
  • MYOGENESIS+0.230
  • SPERMATOGENESIS+0.230
  • HEDGEHOG_SIGNALING+0.220
  • APICAL_JUNCTION+0.210

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.520
  • IL6_JAK_STAT3_SIGNALING-0.440
  • INTERFERON_GAMMA_RESPONSE-0.400
  • INFLAMMATORY_RESPONSE-0.370
  • INTERFERON_ALPHA_RESPONSE-0.370
  • TNFA_SIGNALING_VIA_NFKB-0.350
  • WNT_BETA_CATENIN_SIGNALING-0.230
  • IL2_STAT5_SIGNALING-0.190
  • ESTROGEN_RESPONSE_EARLY-0.180
  • APOPTOSIS-0.170

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-BH-A0HY-01A-11R-A056-07
breast-umap@18
C0.790
2034df4c4-52bd-4025-aee4-ad630d0d00af
melanoma-umap@29
0.772
3s0095123
melanoma-umap@29
0.767
448155bad-7de9-401d-a495-972cbbb8f276
melanoma-umap@29
0.763
5SRR8518245
breast-umap@18
F0.751
6SRR5088861
melanoma-umap@29
0.730
7SRR8518380
breast-umap@18
C0.729
8SRR25617914
breast-umap@18
C0.728
9BSR_19_0079_A1_S53
breast-umap@18
B0.728
10SRR8518158
breast-umap@18
E0.727

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.330Inavolisib— uncovered
MTORC1_SIGNALING0.310Inavolisib— uncovered
ANGIOGENESIS0.300Remibrutinib— uncovered
GLYCOLYSIS0.260Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.250Remibrutinib— uncovered
PROTEIN_SECRETION0.240Remibrutinib— uncovered
MYOGENESIS0.230Inavolisib— uncovered
SPERMATOGENESIS0.230Inavolisib— uncovered
HEDGEHOG_SIGNALING0.220Inavolisib— uncovered
APICAL_JUNCTION0.210Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.210Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.180Inavolisib— uncovered
PANCREAS_BETA_CELLS0.160Cobimetinib— uncovered
FATTY_ACID_METABOLISM0.150Inavolisib— uncovered
HYPOXIA0.150Idelalisib— uncovered
ANDROGEN_RESPONSE0.130Inavolisib— uncovered
G2M_CHECKPOINT0.120Inavolisib— uncovered
MITOTIC_SPINDLE0.120Inavolisib— uncovered
COAGULATION0.080Binimetinib— uncovered
PEROXISOME0.080Idelalisib— uncovered