SRR1351325
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.219
- PROTEIN_SECRETION+0.159
- UNFOLDED_PROTEIN_RESPONSE+0.131
- MYC_TARGETS_V1+0.119
- OXIDATIVE_PHOSPHORYLATION+0.099
- MYC_TARGETS_V2+0.045
- PI3K_AKT_MTOR_SIGNALING+0.030
- MITOTIC_SPINDLE+0.022
- HEME_METABOLISM-0.021
- E2F_TARGETS-0.030
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.635
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.568
- INFLAMMATORY_RESPONSE-0.540
- INTERFERON_GAMMA_RESPONSE-0.536
- ANGIOGENESIS-0.526
- COAGULATION-0.484
- IL6_JAK_STAT3_SIGNALING-0.483
- TGF_BETA_SIGNALING-0.451
- TNFA_SIGNALING_VIA_NFKB-0.451
- ALLOGRAFT_REJECTION-0.433
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1406917 | GTEX | — | 0.991 |
| 2 | SRR1321244 | GTEX | — | 0.990 |
| 3 | SRR1343115 | GTEX | — | 0.989 |
| 4 | SRR1410934 | GTEX | — | 0.989 |
| 5 | SRR1456841 | GTEX | — | 0.988 |
| 6 | SRR1421140 | GTEX | — | 0.987 |
| 7 | SRR1322270 | GTEX | — | 0.986 |
| 8 | SRR1397266 | GTEX | — | 0.986 |
| 9 | SRR1458422 | GTEX | — | 0.986 |
| 10 | SRR663453 | GTEX | — | 0.986 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.219 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.159 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.131 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.119 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.099 | Remibrutinib | — uncovered |
| MYC_TARGETS_V2 | 0.045 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.030 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.022 | Inavolisib | — uncovered |