Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG20

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ba2ad5bd-626e-5beb-b291-27ec4b63c3b0

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • TNFA_SIGNALING_VIA_NFKB+0.649
  • MTORC1_SIGNALING+0.502
  • UNFOLDED_PROTEIN_RESPONSE+0.494
  • HYPOXIA+0.457
  • ANDROGEN_RESPONSE+0.420
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.417
  • TGF_BETA_SIGNALING+0.364
  • MYC_TARGETS_V1+0.340
  • P53_PATHWAY+0.331
  • PROTEIN_SECRETION+0.322

Top 10 suppressed

  • E2F_TARGETS-0.326
  • OXIDATIVE_PHOSPHORYLATION-0.318
  • NOTCH_SIGNALING-0.216
  • BILE_ACID_METABOLISM-0.215
  • DNA_REPAIR-0.157
  • FATTY_ACID_METABOLISM-0.142
  • INTERFERON_ALPHA_RESPONSE-0.136
  • ADIPOGENESIS-0.104
  • ALLOGRAFT_REJECTION-0.094
  • G2M_CHECKPOINT-0.089

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_KP735TJ6
brain-umap@2
high-grade glioma—0.798
2MNG902
mng-umap@100
——0.796
3TCGA-EW-A1PG-01A-11R-A144-07
breast-umap@18
—A0.787
4MNG202
mng-umap@100
——0.775
5TCGA-85-8481-01A-11R-2326-07
lung-landscapes@6
—cohortSQ10.767
6MNG462
mng-umap@100
——0.766
7ULC1700T_S19
lung-landscapes@6
—cohortMD20.760
8MNG932
mng-umap@100
——0.758
9299613f5-2f9a-4687-ab0c-323bf38f3699
melanoma-umap@29
——0.757
10MNG688
mng-umap@100
——0.756

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TNFA_SIGNALING_VIA_NFKB0.649Inavolisib— uncovered
MTORC1_SIGNALING0.502Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.494Idelalisib— uncovered
HYPOXIA0.457Idelalisib— uncovered
ANDROGEN_RESPONSE0.420Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.417Inavolisib— uncovered
TGF_BETA_SIGNALING0.364Inavolisib— uncovered
MYC_TARGETS_V10.340Inavolisib— uncovered
P53_PATHWAY0.331Idelalisib— uncovered
PROTEIN_SECRETION0.322Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.301Idelalisib— uncovered
UV_RESPONSE_UP0.296Idelalisib— uncovered
APOPTOSIS0.285Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.240Remibrutinib— uncovered
IL6_JAK_STAT3_SIGNALING0.224Inavolisib— uncovered
MYC_TARGETS_V20.223Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.209Inavolisib— uncovered
KRAS_SIGNALING_UP0.208Inavolisib— uncovered
GLYCOLYSIS0.203Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.193Inavolisib— uncovered