Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

7AA08B08-B1DD-47AB-A0F2-850F6DE95093

ba6ccbb9-fdfb-5dc6-bb37-55fabf7b4b0d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
20.466491458607095
age_years
40
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
165F93AB7-AA99-49B5-8D59-7D0DE9CA9E34
brain-umap@2
0.962
2DC01D165-E257-49D6-8B9B-37CA7DE398F6
brain-umap@2
0.956
3SRR934949
brain-umap@2
0.952
4795FBB8C-0E74-477F-AA27-1CE97A4E90B9
brain-umap@2
0.952
5A678E1E5-E02D-49A1-BB2B-C91A60E6382E
brain-umap@2
0.952
6D494D692-9EC2-429A-A0FE-696D2A152D4A
brain-umap@2
0.950
7B27956E8-3374-4720-9F80-7CE6FE7C7690
brain-umap@2
0.948
8D5191F3D-028E-401C-927E-483F6884BE39
brain-umap@2
0.946
9SRR934961
brain-umap@2
0.946
107876A884-F031-42AB-ADC0-89589760FB6B
brain-umap@2
0.945

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 42 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TGF_BETA_SIGNALING0.477Inavolisib— uncovered
MYC_TARGETS_V10.458Inavolisib— uncovered
MYC_TARGETS_V20.458Idelalisib— uncovered
DNA_REPAIR0.453Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.443Inavolisib— uncovered
E2F_TARGETS0.436Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.420Inavolisib— uncovered
G2M_CHECKPOINT0.418Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.405Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.392Idelalisib— uncovered
ALLOGRAFT_REJECTION0.387Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.379Idelalisib— uncovered
NOTCH_SIGNALING0.346Inavolisib— uncovered
PROTEIN_SECRETION0.343Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.329Inavolisib— uncovered
MITOTIC_SPINDLE0.327Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.320Inavolisib— uncovered
APOPTOSIS0.315Idelalisib— uncovered
ANDROGEN_RESPONSE0.301Inavolisib— uncovered
ANGIOGENESIS0.299Remibrutinib— uncovered