SRR1432123
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.344
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.168
- SPERMATOGENESIS+0.165
- KRAS_SIGNALING_DN+0.106
- HEDGEHOG_SIGNALING+0.097
- HEME_METABOLISM+0.068
- UV_RESPONSE_UP+0.057
- UV_RESPONSE_DN+0.050
- PI3K_AKT_MTOR_SIGNALING+0.018
- PANCREAS_BETA_CELLS+0.015
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.538
- INTERFERON_ALPHA_RESPONSE-0.499
- INTERFERON_GAMMA_RESPONSE-0.460
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.421
- E2F_TARGETS-0.408
- G2M_CHECKPOINT-0.406
- ALLOGRAFT_REJECTION-0.377
- INFLAMMATORY_RESPONSE-0.368
- NOTCH_SIGNALING-0.360
- COAGULATION-0.349
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1500753 | GTEX | — | 0.967 |
| 2 | SRR814989 | GTEX | — | 0.963 |
| 3 | SRR1416477 | GTEX | — | 0.962 |
| 4 | SRR1354446 | GTEX | — | 0.959 |
| 5 | SRR1408208 | GTEX | — | 0.959 |
| 6 | SRR1084842 | GTEX | — | 0.959 |
| 7 | SRR1453341 | GTEX | — | 0.958 |
| 8 | SRR1459718 | GTEX | — | 0.955 |
| 9 | SRR1471943 | GTEX | — | 0.952 |
| 10 | SRR1389979 | GTEX | — | 0.952 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.344 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.168 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.165 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.106 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.097 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.068 | Temsirolimus | — uncovered |
| UV_RESPONSE_UP | 0.057 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.050 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.018 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.015 | Cobimetinib | — uncovered |