SRR1471943
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.376
- SPERMATOGENESIS+0.291
- PANCREAS_BETA_CELLS+0.185
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.113
- KRAS_SIGNALING_DN+0.109
- PROTEIN_SECRETION+0.064
- HEDGEHOG_SIGNALING+0.056
- HEME_METABOLISM-0.021
- PI3K_AKT_MTOR_SIGNALING-0.022
- APICAL_SURFACE-0.035
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.618
- INTERFERON_ALPHA_RESPONSE-0.612
- INTERFERON_GAMMA_RESPONSE-0.565
- INFLAMMATORY_RESPONSE-0.530
- TNFA_SIGNALING_VIA_NFKB-0.496
- ANGIOGENESIS-0.491
- NOTCH_SIGNALING-0.486
- ALLOGRAFT_REJECTION-0.485
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.477
- COAGULATION-0.446
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1455925 | GTEX | — | 0.990 |
| 2 | SRR1323106 | GTEX | — | 0.989 |
| 3 | SRR821626 | GTEX | — | 0.978 |
| 4 | SRR1341365 | GTEX | — | 0.978 |
| 5 | SRR1084842 | GTEX | — | 0.977 |
| 6 | SRR1354446 | GTEX | — | 0.976 |
| 7 | SRR1500753 | GTEX | — | 0.974 |
| 8 | SRR1360563 | GTEX | — | 0.971 |
| 9 | SRR1317344 | GTEX | — | 0.970 |
| 10 | SRR1349056 | GTEX | — | 0.970 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.376 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.291 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.185 | Cobimetinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.113 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.109 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.064 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.056 | Inavolisib | — uncovered |