SRR5088921
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.400
- MYC_TARGETS_V1+0.400
- MYC_TARGETS_V2+0.400
- PROTEIN_SECRETION+0.300
- UNFOLDED_PROTEIN_RESPONSE+0.300
- MITOTIC_SPINDLE+0.200
- WNT_BETA_CATENIN_SIGNALING+0.200
- DNA_REPAIR+0.100
- PI3K_AKT_MTOR_SIGNALING+0.100
- E2F_TARGETS+0.000
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.600
- ALLOGRAFT_REJECTION-0.500
- ANGIOGENESIS-0.500
- IL6_JAK_STAT3_SIGNALING-0.500
- APICAL_SURFACE-0.400
- INFLAMMATORY_RESPONSE-0.400
- PANCREAS_BETA_CELLS-0.400
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- XENOBIOTIC_METABOLISM-0.400
- APICAL_JUNCTION-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR5088920 | — | — | 0.976 |
| 2 | fe4a0710-a6db-4735-9d1a-113df310def6 | — | — | 0.903 |
| 3 | TCGA-GC-A3BM-01A-11R-A22U-07 | — | — | 0.877 |
| 4 | MDT-AP-3315 | Med | Medulloblastoma | 0.862 |
| 5 | MDT-AP-0329 | Med | Medulloblastoma | 0.844 |
| 6 | R337 | — | — | 0.832 |
| 7 | BS_2A5R9MEJ | high-grade glioma | — | 0.823 |
| 8 | MNG861 | — | — | 0.823 |
| 9 | TCGA-A2-A0ET-01A-31R-A034-07 | — | B | 0.819 |
| 10 | SRR4195674 | — | — | 0.814 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.400 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.400 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.400 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.300 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.300 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.200 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.200 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.100 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.100 | Inavolisib | — uncovered |