fe4a0710-a6db-4735-9d1a-113df310def6
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.400
- PROTEIN_SECRETION+0.300
- DNA_REPAIR+0.200
- MITOTIC_SPINDLE+0.200
- UNFOLDED_PROTEIN_RESPONSE+0.200
- MYC_TARGETS_V2+0.100
- OXIDATIVE_PHOSPHORYLATION+0.100
- PI3K_AKT_MTOR_SIGNALING+0.100
- E2F_TARGETS+0.000
- G2M_CHECKPOINT+0.000
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.600
- ALLOGRAFT_REJECTION-0.500
- APICAL_SURFACE-0.500
- IL6_JAK_STAT3_SIGNALING-0.500
- INFLAMMATORY_RESPONSE-0.500
- KRAS_SIGNALING_UP-0.500
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.500
- TNFA_SIGNALING_VIA_NFKB-0.500
- ANGIOGENESIS-0.400
- COAGULATION-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR5088921 | — | — | 0.903 |
| 2 | SRR5088920 | — | — | 0.898 |
| 3 | MDT-AP-0329 | Med | Medulloblastoma | 0.892 |
| 4 | SRR2780299 | — | — | 0.859 |
| 5 | SRR1797246 | — | cohortSC | 0.856 |
| 6 | SRR655864 | GTEX | — | 0.853 |
| 7 | R337 | — | — | 0.853 |
| 8 | TCGA-A8-A06N-01A-11R-A00Z-07 | — | B | 0.847 |
| 9 | MNG823 | — | — | 0.846 |
| 10 | SRR4195674 | — | — | 0.846 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.400 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.300 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.200 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.200 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.200 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.100 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.100 | Remibrutinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.100 | Inavolisib | — uncovered |