bd844a66-bb61-4ba1-9301-1bdeec35620f
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 41
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.300
- PANCREAS_BETA_CELLS+0.290
- BILE_ACID_METABOLISM+0.140
- DNA_REPAIR+0.120
- PEROXISOME+0.110
- MYC_TARGETS_V2+0.090
- ADIPOGENESIS+0.080
- XENOBIOTIC_METABOLISM+0.070
- KRAS_SIGNALING_DN+0.020
- MYC_TARGETS_V1+0.000
Top 10 suppressed
- ANGIOGENESIS-0.600
- INTERFERON_ALPHA_RESPONSE-0.520
- INTERFERON_GAMMA_RESPONSE-0.490
- TNFA_SIGNALING_VIA_NFKB-0.450
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.410
- HYPOXIA-0.360
- ALLOGRAFT_REJECTION-0.330
- HEDGEHOG_SIGNALING-0.330
- INFLAMMATORY_RESPONSE-0.320
- TGF_BETA_SIGNALING-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-55-6972-01A-11R-1949-07 | — | cohortA2 | 0.907 |
| 2 | TCGA-E5-A4U1-01A-11R-A31N-07 | — | — | 0.890 |
| 3 | SRR8518209 | — | C | 0.886 |
| 4 | TCGA-LL-A6FP-01A-11R-A31O-07 | — | B | 0.886 |
| 5 | cf2834ac-00ed-4372-be25-042f38241196 | — | — | 0.885 |
| 6 | TCGA-DK-AA75-01A-11R-A39I-07 | — | — | 0.884 |
| 7 | R16 | — | — | 0.884 |
| 8 | s0112301 | — | — | 0.880 |
| 9 | MDT-AP-2119 | Med | Medulloblastoma | 0.879 |
| 10 | SRR4296068 | — | cohortA1 | 0.876 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.300 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.290 | Cobimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.140 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.120 | Idelalisib | — uncovered |
| PEROXISOME | 0.110 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.090 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.080 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.070 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |